Pertussis and pertussis-like syndrome in young children
The most common infectious diseases with a risk of severe, non-smooth course and unfavorable outcome in young children, including the first year of life, are pertussis and respiratory syncytial viral infection (RSV infection), often occurring with pertussis-like syndrome.Objective: to establish clin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2021-12-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/643 |
| _version_ | 1826547023938060288 |
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| author | I. V. Babachenko N. S. Tian Yu. V. Nesterova |
| author_facet | I. V. Babachenko N. S. Tian Yu. V. Nesterova |
| author_sort | I. V. Babachenko |
| collection | DOAJ |
| description | The most common infectious diseases with a risk of severe, non-smooth course and unfavorable outcome in young children, including the first year of life, are pertussis and respiratory syncytial viral infection (RSV infection), often occurring with pertussis-like syndrome.Objective: to establish clinical and laboratory differential diagnostic criteria for pertussis and RSV infection in children of the first year of life.Materials and methods: A retrospective comparative study was conducted, which included patients of the first year of life (from 1 month to 11 months and 29 days), regardless of the duration of hospitalization and duration of the disease: 48 patients with pertussis and 26 with acute RSV infection.Results: The compared groups of patients were comparable in age, the number of severe forms (4.6 ± 0.5 months, 17% for pertussis and 4.0 ± 0.2 months, 16% for RS infection). The disease in both cases began subacute, however, with RSV infection 92% of children were hospitalized in the first 5 days from the onset of the disease, with pertussis — in the first week of the period of convulsive cough — 47.9%, in the second week — 41.7%, in the third week — 10.4%. 52% of patients with RSV infection had no fever or (in 32%) did not exceed 1—3 days. In 41.3% of patients it was subfebrile (37—38 °C), in 21.1% it was febrile (38—39 °C). In patients with pertussis the onset of the disease took place against the background of normal body temperature. In patients with RSV infection, bronchiolitis was recorded in 24% of cases, obstructive bronchitis — in 60%. Patients with pertussis, 89.6% of whom were not vaccinated and 10.4% did not complete the initial course of vaccination, had a typical paroxysmal cough with reprises. Complications in the form of respiratory rhythm disturbances were recorded in 14.6% of cases, pneumonia — in 6.3%. Comparison of hematological parameters revealed highly significant differences in the levels of leukocytosis and relative lymphocytosis (p < 0.001), as well as thrombocytosis (p < 0.01), with the predominance of all indicators in patients with pertussis.Conclusion. Differential diagnostic criteria for the similarity of the clinical picture may be established hematological differences: pronounced leukocytosis due to lymphocytosis, increasing in dynamics, and thrombocytosis in pertussis and normocytosis with moderate lymphocytosis, a possible tendency to thrombocytosis in severe RSV infection. |
| first_indexed | 2024-04-10T03:23:57Z |
| format | Article |
| id | doaj.art-143b10d7f62243ee81cd1a48ffdb228b |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2025-03-14T05:43:04Z |
| publishDate | 2021-12-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-143b10d7f62243ee81cd1a48ffdb228b2025-03-05T13:50:45ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072021-12-01204535910.22627/2072-8107-2021-20-4-53-59533Pertussis and pertussis-like syndrome in young childrenI. V. Babachenko0N. S. Tian1Yu. V. Nesterova2Saint-Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation; Pediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesThe most common infectious diseases with a risk of severe, non-smooth course and unfavorable outcome in young children, including the first year of life, are pertussis and respiratory syncytial viral infection (RSV infection), often occurring with pertussis-like syndrome.Objective: to establish clinical and laboratory differential diagnostic criteria for pertussis and RSV infection in children of the first year of life.Materials and methods: A retrospective comparative study was conducted, which included patients of the first year of life (from 1 month to 11 months and 29 days), regardless of the duration of hospitalization and duration of the disease: 48 patients with pertussis and 26 with acute RSV infection.Results: The compared groups of patients were comparable in age, the number of severe forms (4.6 ± 0.5 months, 17% for pertussis and 4.0 ± 0.2 months, 16% for RS infection). The disease in both cases began subacute, however, with RSV infection 92% of children were hospitalized in the first 5 days from the onset of the disease, with pertussis — in the first week of the period of convulsive cough — 47.9%, in the second week — 41.7%, in the third week — 10.4%. 52% of patients with RSV infection had no fever or (in 32%) did not exceed 1—3 days. In 41.3% of patients it was subfebrile (37—38 °C), in 21.1% it was febrile (38—39 °C). In patients with pertussis the onset of the disease took place against the background of normal body temperature. In patients with RSV infection, bronchiolitis was recorded in 24% of cases, obstructive bronchitis — in 60%. Patients with pertussis, 89.6% of whom were not vaccinated and 10.4% did not complete the initial course of vaccination, had a typical paroxysmal cough with reprises. Complications in the form of respiratory rhythm disturbances were recorded in 14.6% of cases, pneumonia — in 6.3%. Comparison of hematological parameters revealed highly significant differences in the levels of leukocytosis and relative lymphocytosis (p < 0.001), as well as thrombocytosis (p < 0.01), with the predominance of all indicators in patients with pertussis.Conclusion. Differential diagnostic criteria for the similarity of the clinical picture may be established hematological differences: pronounced leukocytosis due to lymphocytosis, increasing in dynamics, and thrombocytosis in pertussis and normocytosis with moderate lymphocytosis, a possible tendency to thrombocytosis in severe RSV infection.https://detinf.elpub.ru/jour/article/view/643pertussisrespiratory syncytial viral infectionrsv infectionchildren of the first year of lifeleukocytosis with lymphocytosisthrombocytosis |
| spellingShingle | I. V. Babachenko N. S. Tian Yu. V. Nesterova Pertussis and pertussis-like syndrome in young children Детские инфекции (Москва) pertussis respiratory syncytial viral infection rsv infection children of the first year of life leukocytosis with lymphocytosis thrombocytosis |
| title | Pertussis and pertussis-like syndrome in young children |
| title_full | Pertussis and pertussis-like syndrome in young children |
| title_fullStr | Pertussis and pertussis-like syndrome in young children |
| title_full_unstemmed | Pertussis and pertussis-like syndrome in young children |
| title_short | Pertussis and pertussis-like syndrome in young children |
| title_sort | pertussis and pertussis like syndrome in young children |
| topic | pertussis respiratory syncytial viral infection rsv infection children of the first year of life leukocytosis with lymphocytosis thrombocytosis |
| url | https://detinf.elpub.ru/jour/article/view/643 |
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