Splice isoform-specific suppression of the CaV2.1 variant underlying spinocerebellar ataxia type 6

Splice isoform-specific suppression of the CaV2.1 variant underlying spinocerebellar ataxia type 6

Spinocerebellar ataxia type 6 (SCA6) is an inherited neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the CaV2.1 voltage-gated calcium channel subunit (CACNA1A). There is currently no treatment for this debilitating disorder and thus a pressing need to develop preventative th...

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Bibliographic Details
Main Authors: Wei-Ling Tsou, Bing-Wen Soong, Henry L. Paulson, Edgardo Rodríguez-Lebrón
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
Autosomal dominant disorder
Spinocerebellar ataxia
Polyglutamine
Cav2.1
CACNA1A
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001331

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