Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents
G-quadruplexes have gained prominence over the past two decades for their role in gene regulation, control of anti-tumour activity and ageing. The physiological relevance and significance of these non-canonical structures in the context of cancer has been reviewed several times. Putative roles of G-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/4/752 |
| _version_ | 1818925499716468736 |
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| author | Pallavi Chilka Nakshi Desai Bhaskar Datta |
| author_facet | Pallavi Chilka Nakshi Desai Bhaskar Datta |
| author_sort | Pallavi Chilka |
| collection | DOAJ |
| description | G-quadruplexes have gained prominence over the past two decades for their role in gene regulation, control of anti-tumour activity and ageing. The physiological relevance and significance of these non-canonical structures in the context of cancer has been reviewed several times. Putative roles of G-quadruplexes in cancer prognosis and pathogenesis have spurred the search for small molecule ligands that are capable of binding and modulating the effect of such structures. On a related theme, small molecule fluorescent probes have emerged that are capable of selective recognition of G-quadruplex structures. These have opened up the possibility of direct visualization and tracking of such structures. In this review we outline recent developments on G-quadruplex specific small molecule fluorescent probes for visualizing G-quadruplexes. The molecules represent a variety of structural scaffolds, mechanism of quadruplex-recognition and fluorescence signal transduction. Quadruplex selectivity and in vivo imaging potential of these molecules places them uniquely as quadruplex-theranostic agents in the predominantly cancer therapeutic context of quadruplex-selective ligands. |
| first_indexed | 2024-12-20T02:42:12Z |
| format | Article |
| id | doaj.art-143ce1a8a8384b548c534317cd0d7584 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T02:42:12Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-143ce1a8a8384b548c534317cd0d75842022-12-21T19:56:16ZengMDPI AGMolecules1420-30492019-02-0124475210.3390/molecules24040752molecules24040752Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic AgentsPallavi Chilka0Nakshi Desai1Bhaskar Datta2Department of Biological Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat 382355, IndiaDepartment of Biological Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat 382355, IndiaDepartment of Biological Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat 382355, IndiaG-quadruplexes have gained prominence over the past two decades for their role in gene regulation, control of anti-tumour activity and ageing. The physiological relevance and significance of these non-canonical structures in the context of cancer has been reviewed several times. Putative roles of G-quadruplexes in cancer prognosis and pathogenesis have spurred the search for small molecule ligands that are capable of binding and modulating the effect of such structures. On a related theme, small molecule fluorescent probes have emerged that are capable of selective recognition of G-quadruplex structures. These have opened up the possibility of direct visualization and tracking of such structures. In this review we outline recent developments on G-quadruplex specific small molecule fluorescent probes for visualizing G-quadruplexes. The molecules represent a variety of structural scaffolds, mechanism of quadruplex-recognition and fluorescence signal transduction. Quadruplex selectivity and in vivo imaging potential of these molecules places them uniquely as quadruplex-theranostic agents in the predominantly cancer therapeutic context of quadruplex-selective ligands.https://www.mdpi.com/1420-3049/24/4/752G-quadruplexesG-quadruplex probeoncogene promotercancer theranosticquadruplex visualization |
| spellingShingle | Pallavi Chilka Nakshi Desai Bhaskar Datta Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents Molecules G-quadruplexes G-quadruplex probe oncogene promoter cancer theranostic quadruplex visualization |
| title | Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents |
| title_full | Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents |
| title_fullStr | Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents |
| title_full_unstemmed | Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents |
| title_short | Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents |
| title_sort | small molecule fluorescent probes for g quadruplex visualization as potential cancer theranostic agents |
| topic | G-quadruplexes G-quadruplex probe oncogene promoter cancer theranostic quadruplex visualization |
| url | https://www.mdpi.com/1420-3049/24/4/752 |
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