Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease
Parkinson’s disease (PD) impairs the control of movement and cognition, including the planning of action and its consequences. This provides the opportunity to study the dopaminergic influences on the perception and awareness of action. Here we examined the perception of the outcome of a goal-direct...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Psychology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01514/full |
| _version_ | 1818130294289465344 |
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| author | Noham eWolpe Noham eWolpe Cristina eNombela Cristina eNombela James eRowe James eRowe James eRowe |
| author_facet | Noham eWolpe Noham eWolpe Cristina eNombela Cristina eNombela James eRowe James eRowe James eRowe |
| author_sort | Noham eWolpe |
| collection | DOAJ |
| description | Parkinson’s disease (PD) impairs the control of movement and cognition, including the planning of action and its consequences. This provides the opportunity to study the dopaminergic influences on the perception and awareness of action. Here we examined the perception of the outcome of a goal-directed action made by medicated patients with PD. A visuomotor task probed the integration of sensorimotor signals with the positive expectations of outcomes (Self priors), which in healthy adults bias perception towards success in proportion to trait optimism. We tested the hypotheses that (i) the priors on the perception of the consequences of one’s own actions differ between patients and age- and sex-matched controls, and (ii) that these priors are modulated by the levodopa dose equivalent in patients. There was no overall difference between patients and controls in the perceptual priors used. However, the precision of patient priors was inversely related to their levodopa dose equivalent. Patients with high levodopa dose equivalent showed more accurate priors, representing predictions that were closer to the true distribution of performance. Such accuracy has previously been demonstrated when observing the actions of others, suggesting abnormal awareness of action in these patients. These results confirm a link between dopamine and the positive expectation of the outcome of one’s own actions, and may have implications for the management of PD. |
| first_indexed | 2024-12-11T08:02:45Z |
| format | Article |
| id | doaj.art-143e0d5999f24b8a84ca99c74fbb81b8 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-11T08:02:45Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-143e0d5999f24b8a84ca99c74fbb81b82022-12-22T01:15:04ZengFrontiers Media S.A.Frontiers in Psychology1664-10782015-10-01610.3389/fpsyg.2015.01514160419Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s diseaseNoham eWolpe0Noham eWolpe1Cristina eNombela2Cristina eNombela3James eRowe4James eRowe5James eRowe6University of CambridgeMedical Research CouncilUniversity of CambridgeMedical Research CouncilUniversity of CambridgeMedical Research CouncilUniversity of CambridgeParkinson’s disease (PD) impairs the control of movement and cognition, including the planning of action and its consequences. This provides the opportunity to study the dopaminergic influences on the perception and awareness of action. Here we examined the perception of the outcome of a goal-directed action made by medicated patients with PD. A visuomotor task probed the integration of sensorimotor signals with the positive expectations of outcomes (Self priors), which in healthy adults bias perception towards success in proportion to trait optimism. We tested the hypotheses that (i) the priors on the perception of the consequences of one’s own actions differ between patients and age- and sex-matched controls, and (ii) that these priors are modulated by the levodopa dose equivalent in patients. There was no overall difference between patients and controls in the perceptual priors used. However, the precision of patient priors was inversely related to their levodopa dose equivalent. Patients with high levodopa dose equivalent showed more accurate priors, representing predictions that were closer to the true distribution of performance. Such accuracy has previously been demonstrated when observing the actions of others, suggesting abnormal awareness of action in these patients. These results confirm a link between dopamine and the positive expectation of the outcome of one’s own actions, and may have implications for the management of PD.http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01514/fullDopamineParkinson's diseasesense of agencyvoluntary actionPlacebo EffectPositive expectations |
| spellingShingle | Noham eWolpe Noham eWolpe Cristina eNombela Cristina eNombela James eRowe James eRowe James eRowe Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease Frontiers in Psychology Dopamine Parkinson's disease sense of agency voluntary action Placebo Effect Positive expectations |
| title | Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease |
| title_full | Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease |
| title_fullStr | Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease |
| title_full_unstemmed | Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease |
| title_short | Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease |
| title_sort | dopaminergic modulation of positive expectations for goal directed action evidence from parkinson s disease |
| topic | Dopamine Parkinson's disease sense of agency voluntary action Placebo Effect Positive expectations |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01514/full |
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