EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION
<p><strong>Aim.</strong> To evaluate effects of angiotensin converting enzyme inhibitor spirapril on efficacy of preventive antiarrhythmic therapy in patients with paroxysmal atrial fibrillation (AF).</p><p><strong>Material and methods.</strong> 40 patients...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-12-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | http://www.rpcardio.ru/jour/article/view/545 |
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| author | L. N. Chikhireva V. I. Malahov E. S. Bykova S. F. Sokolov |
| author_facet | L. N. Chikhireva V. I. Malahov E. S. Bykova S. F. Sokolov |
| author_sort | L. N. Chikhireva |
| collection | DOAJ |
| description | <p><strong>Aim.</strong> To evaluate effects of angiotensin converting enzyme inhibitor spirapril on efficacy of preventive antiarrhythmic therapy in patients with paroxysmal atrial fibrillation (AF).</p><p><strong>Material and methods.</strong> 40 patients with paroxysmal AF were involved in open-label, cross-over study with periods of antiarrhythmic drug withdrawal. During 3 months all patients received by turns two types of therapy: combination of preventive antiarrhythmic therapy with spirapril 6 mg once daily - (CT group) or preventive antiarrhythmic therapy only (AT group).</p><p><strong>Results.</strong> AF-free intervals to the first and the second AF paroxysms during antiarrhythmic drug withdrawal were comparable ) in AT and CT groups (p=0,4 and p=0,6, respectively, logrank test).</p><p><strong>Conclusion.</strong> Spirapril added to the basic preventive antiarrhythmic therapy during 3 months had no effect on the length of interictal period in paroxysmal AF.</p> |
| first_indexed | 2024-03-12T09:01:24Z |
| format | Article |
| id | doaj.art-143f305257844d73a518e36ed542289b |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T09:01:24Z |
| publishDate | 2015-12-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-143f305257844d73a518e36ed542289b2023-09-02T15:37:05ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-12-0135455310.1234/1819-6446-2007-5-45-53545EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATIONL. N. Chikhireva0V. I. Malahov1E. S. Bykova2S. F. Sokolov3Российский кардиологический научно-производственный комплекс Росмедтехнологий, Институт клинической кардиологии им. А.Л. Мясникова, МоскваРоссийский кардиологический научно-производственный комплекс Росмедтехнологий, Институт клинической кардиологии им. А.Л. Мясникова, МоскваРоссийский кардиологический научно-производственный комплекс Росмедтехнологий, Институт клинической кардиологии им. А.Л. Мясникова, МоскваРоссийский кардиологический научно-производственный комплекс Росмедтехнологий, Институт клинической кардиологии им. А.Л. Мясникова, Москва<p><strong>Aim.</strong> To evaluate effects of angiotensin converting enzyme inhibitor spirapril on efficacy of preventive antiarrhythmic therapy in patients with paroxysmal atrial fibrillation (AF).</p><p><strong>Material and methods.</strong> 40 patients with paroxysmal AF were involved in open-label, cross-over study with periods of antiarrhythmic drug withdrawal. During 3 months all patients received by turns two types of therapy: combination of preventive antiarrhythmic therapy with spirapril 6 mg once daily - (CT group) or preventive antiarrhythmic therapy only (AT group).</p><p><strong>Results.</strong> AF-free intervals to the first and the second AF paroxysms during antiarrhythmic drug withdrawal were comparable ) in AT and CT groups (p=0,4 and p=0,6, respectively, logrank test).</p><p><strong>Conclusion.</strong> Spirapril added to the basic preventive antiarrhythmic therapy during 3 months had no effect on the length of interictal period in paroxysmal AF.</p>http://www.rpcardio.ru/jour/article/view/545пароксизмальная мерцательная аритмияингибиторы ангиотензин-превращающего ферментаспираприлантиаритмическая терапия |
| spellingShingle | L. N. Chikhireva V. I. Malahov E. S. Bykova S. F. Sokolov EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION Рациональная фармакотерапия в кардиологии пароксизмальная мерцательная аритмия ингибиторы ангиотензин-превращающего фермента спираприл антиаритмическая терапия |
| title | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_full | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_fullStr | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_full_unstemmed | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_short | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_sort | effect of spirapril on the length of interictal interval in paroxysmal atrial fibrillation |
| topic | пароксизмальная мерцательная аритмия ингибиторы ангиотензин-превращающего фермента спираприл антиаритмическая терапия |
| url | http://www.rpcardio.ru/jour/article/view/545 |
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