Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems
Time- and site-specific release of bioactive compounds mediated by microcontainers immobilized on a surface is of high importance in a variety of tasks related to biomedicine and functional coatings. In the present work, we investigate arrays of hollow microchambers formed by composite shells based...
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| Format: | Article |
| Language: | English |
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Saratov State University
2020-11-01
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| Series: | Известия Саратовского университета. Новая серия Серия: Физика |
| Subjects: | |
| Online Access: | https://fizika.sgu.ru/sites/fizika.sgu.ru/files/text-pdf/2020/11/fizika_2020_4_311-314.pdf |
| _version_ | 1818876098387116032 |
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| author | Ermakov, Alexey Vadimovich Lengert, Ekaterina Vladimirovna Saveleva, Mariia Sergeevna Sukhorukov, Gleb Borisovich |
| author_facet | Ermakov, Alexey Vadimovich Lengert, Ekaterina Vladimirovna Saveleva, Mariia Sergeevna Sukhorukov, Gleb Borisovich |
| author_sort | Ermakov, Alexey Vadimovich |
| collection | DOAJ |
| description | Time- and site-specific release of bioactive compounds mediated by microcontainers immobilized on a surface is of high importance in a variety of tasks related to biomedicine and functional coatings. In the present work, we investigate arrays of hollow microchambers formed by composite shells based on a polylactic acid matrix and single-walled carbon nanotubes filler with high responsiveness towards electric current stimuli. The monitoring of the morphology changes reveals significant damages to the shells of microchambers formed by conductive composite material. The voltage of 3 V is shown to be sufficient to induce thermal damages to the microchambers. This study demonstrates the in-principle possibility to realize the opening of polylactic acid-based microchambers by application of low-power currents. The developed system opens a promising avenue for implantable delivery routes in a number of areas related to smart coatings, time and site-specific release. We believe these results will find application in the development of new implantable drug depot systems in biomedicine and cosmetology. |
| first_indexed | 2024-12-19T13:36:59Z |
| format | Article |
| id | doaj.art-14406da2c71544f68dbb5336d803b547 |
| institution | Directory Open Access Journal |
| issn | 1817-3020 2542-193X |
| language | English |
| last_indexed | 2024-12-19T13:36:59Z |
| publishDate | 2020-11-01 |
| publisher | Saratov State University |
| record_format | Article |
| series | Известия Саратовского университета. Новая серия Серия: Физика |
| spelling | doaj.art-14406da2c71544f68dbb5336d803b5472022-12-21T20:19:10ZengSaratov State UniversityИзвестия Саратовского университета. Новая серия Серия: Физика1817-30202542-193X2020-11-0120431131410.18500/1817-3020-2020-20-4-311-314Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot SystemsErmakov, Alexey Vadimovich0Lengert, Ekaterina Vladimirovna1Saveleva, Mariia Sergeevna2Sukhorukov, Gleb Borisovich3Saratov State University, 410012, Russia, Saratov, Astrakhanskaya street, 83Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 RussiaSaratov State University, 410012, Russia, Saratov, Astrakhanskaya street, 83Queen Mary University of London, Mile End Road, London E1 4NS, UKTime- and site-specific release of bioactive compounds mediated by microcontainers immobilized on a surface is of high importance in a variety of tasks related to biomedicine and functional coatings. In the present work, we investigate arrays of hollow microchambers formed by composite shells based on a polylactic acid matrix and single-walled carbon nanotubes filler with high responsiveness towards electric current stimuli. The monitoring of the morphology changes reveals significant damages to the shells of microchambers formed by conductive composite material. The voltage of 3 V is shown to be sufficient to induce thermal damages to the microchambers. This study demonstrates the in-principle possibility to realize the opening of polylactic acid-based microchambers by application of low-power currents. The developed system opens a promising avenue for implantable delivery routes in a number of areas related to smart coatings, time and site-specific release. We believe these results will find application in the development of new implantable drug depot systems in biomedicine and cosmetology.https://fizika.sgu.ru/sites/fizika.sgu.ru/files/text-pdf/2020/11/fizika_2020_4_311-314.pdfmicrochamberscomposite materialpolylactic acidcarbon nanotubes |
| spellingShingle | Ermakov, Alexey Vadimovich Lengert, Ekaterina Vladimirovna Saveleva, Mariia Sergeevna Sukhorukov, Gleb Borisovich Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems Известия Саратовского университета. Новая серия Серия: Физика microchambers composite material polylactic acid carbon nanotubes |
| title | Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems |
| title_full | Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems |
| title_fullStr | Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems |
| title_full_unstemmed | Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems |
| title_short | Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems |
| title_sort | electrically induced opening of composite pla swcnt microchambers for implantable drug depot systems |
| topic | microchambers composite material polylactic acid carbon nanotubes |
| url | https://fizika.sgu.ru/sites/fizika.sgu.ru/files/text-pdf/2020/11/fizika_2020_4_311-314.pdf |
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