Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil
Objective: To present the frequency of single nucleotide polymorphismsof a few immune response genes in a population sample from SãoPaulo City (SP), Brazil. Methods: Data on allele frequencies ofknown polymorphisms of innate and acquired immunity genes werepresented, the majority with proven impact...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2011-09-01
|
| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://apps.einstein.br/revista/arquivos/PDF/1866-Einstein_v9n3_359-366_ingles.pdf |
| _version_ | 1811202272784285696 |
|---|---|
| author | Léa Campos de Oliveira Rajendranath Ramasawmy Jaila Dias Borges Maria Lucia Carnevale Marin Natalie Guida Muller Jorge Kalil Anna Carla Goldberg |
| author_facet | Léa Campos de Oliveira Rajendranath Ramasawmy Jaila Dias Borges Maria Lucia Carnevale Marin Natalie Guida Muller Jorge Kalil Anna Carla Goldberg |
| author_sort | Léa Campos de Oliveira |
| collection | DOAJ |
| description | Objective: To present the frequency of single nucleotide polymorphismsof a few immune response genes in a population sample from SãoPaulo City (SP), Brazil. Methods: Data on allele frequencies ofknown polymorphisms of innate and acquired immunity genes werepresented, the majority with proven impact on gene function. Datawere gathered from a sample of healthy individuals, non-HLA identicalsiblings of bone marrow transplant recipients from the Hospital dasClínicas da Faculdade de Medicina da Universidade de São Paulo,obtained between 1998 and 2005. The number of samples variedfor each single nucleotide polymorphism analyzed by polymerasechain reaction followed by restriction enzyme cleavage. Results:Allele and genotype distribution of 41 different gene polymorphisms,mostly cytokines, but also including other immune response genes,were presented. Conclusion: We believe that the data presentedhere can be of great value for case-control studies, to define whichpolymorphisms are present in biologically relevant frequencies and toassess targets for therapeutic intervention in polygenic diseases witha component of immune and inflammatory responses. |
| first_indexed | 2024-04-12T02:37:15Z |
| format | Article |
| id | doaj.art-1440dac97b484b17b8adca3669584ea1 |
| institution | Directory Open Access Journal |
| issn | 1679-4508 |
| language | English |
| last_indexed | 2024-04-12T02:37:15Z |
| publishDate | 2011-09-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-1440dac97b484b17b8adca3669584ea12022-12-22T03:51:28ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082011-09-0193359366Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, BrazilLéa Campos de OliveiraRajendranath RamasawmyJaila Dias BorgesMaria Lucia Carnevale MarinNatalie Guida MullerJorge KalilAnna Carla GoldbergObjective: To present the frequency of single nucleotide polymorphismsof a few immune response genes in a population sample from SãoPaulo City (SP), Brazil. Methods: Data on allele frequencies ofknown polymorphisms of innate and acquired immunity genes werepresented, the majority with proven impact on gene function. Datawere gathered from a sample of healthy individuals, non-HLA identicalsiblings of bone marrow transplant recipients from the Hospital dasClínicas da Faculdade de Medicina da Universidade de São Paulo,obtained between 1998 and 2005. The number of samples variedfor each single nucleotide polymorphism analyzed by polymerasechain reaction followed by restriction enzyme cleavage. Results:Allele and genotype distribution of 41 different gene polymorphisms,mostly cytokines, but also including other immune response genes,were presented. Conclusion: We believe that the data presentedhere can be of great value for case-control studies, to define whichpolymorphisms are present in biologically relevant frequencies and toassess targets for therapeutic intervention in polygenic diseases witha component of immune and inflammatory responses.http://apps.einstein.br/revista/arquivos/PDF/1866-Einstein_v9n3_359-366_ingles.pdfPolymorphismgeneticImmunityinnateCytokines |
| spellingShingle | Léa Campos de Oliveira Rajendranath Ramasawmy Jaila Dias Borges Maria Lucia Carnevale Marin Natalie Guida Muller Jorge Kalil Anna Carla Goldberg Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil Einstein (São Paulo) Polymorphism genetic Immunity innate Cytokines |
| title | Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil |
| title_full | Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil |
| title_fullStr | Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil |
| title_full_unstemmed | Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil |
| title_short | Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil |
| title_sort | frequency of single nucleotide polymorphisms of some immune response genes in a population sample from sao paulo brazil |
| topic | Polymorphism genetic Immunity innate Cytokines |
| url | http://apps.einstein.br/revista/arquivos/PDF/1866-Einstein_v9n3_359-366_ingles.pdf |
| work_keys_str_mv | AT leacamposdeoliveira frequencyofsinglenucleotidepolymorphismsofsomeimmuneresponsegenesinapopulationsamplefromsaopaulobrazil AT rajendranathramasawmy frequencyofsinglenucleotidepolymorphismsofsomeimmuneresponsegenesinapopulationsamplefromsaopaulobrazil AT jailadiasborges frequencyofsinglenucleotidepolymorphismsofsomeimmuneresponsegenesinapopulationsamplefromsaopaulobrazil AT marialuciacarnevalemarin frequencyofsinglenucleotidepolymorphismsofsomeimmuneresponsegenesinapopulationsamplefromsaopaulobrazil AT natalieguidamuller frequencyofsinglenucleotidepolymorphismsofsomeimmuneresponsegenesinapopulationsamplefromsaopaulobrazil AT jorgekalil frequencyofsinglenucleotidepolymorphismsofsomeimmuneresponsegenesinapopulationsamplefromsaopaulobrazil AT annacarlagoldberg frequencyofsinglenucleotidepolymorphismsofsomeimmuneresponsegenesinapopulationsamplefromsaopaulobrazil |