Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
Abstract Diagnosing Parkinson’s disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subseq...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-021-00261-z |
| _version_ | 1827617118017814528 |
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| author | Jingheng Zhou Jicheng Li Amy B. Papaneri Nicholas P. Kobzar Guohong Cui |
| author_facet | Jingheng Zhou Jicheng Li Amy B. Papaneri Nicholas P. Kobzar Guohong Cui |
| author_sort | Jingheng Zhou |
| collection | DOAJ |
| description | Abstract Diagnosing Parkinson’s disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subsequently measuring the levels of dopamine metabolites in the cerebrospinal fluid and plasma, a hypodopaminergic state can be revealed when less than 30% of dopamine neurons are lost in mouse PD models. These findings may lead to sensitive and practical screening and diagnostic tests for detecting early PD in the high-risk population. |
| first_indexed | 2024-03-09T09:38:28Z |
| format | Article |
| id | doaj.art-144317510e56488fa2d81fe1b1a64459 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T09:38:28Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-144317510e56488fa2d81fe1b1a644592023-12-02T01:10:15ZengNature Portfolionpj Parkinson's Disease2373-80572021-12-01711810.1038/s41531-021-00261-zDopamine Neuron Challenge Test for early detection of Parkinson’s diseaseJingheng Zhou0Jicheng Li1Amy B. Papaneri2Nicholas P. Kobzar3Guohong Cui4In Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthIn Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthIn Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthIn Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthIn Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthAbstract Diagnosing Parkinson’s disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subsequently measuring the levels of dopamine metabolites in the cerebrospinal fluid and plasma, a hypodopaminergic state can be revealed when less than 30% of dopamine neurons are lost in mouse PD models. These findings may lead to sensitive and practical screening and diagnostic tests for detecting early PD in the high-risk population.https://doi.org/10.1038/s41531-021-00261-z |
| spellingShingle | Jingheng Zhou Jicheng Li Amy B. Papaneri Nicholas P. Kobzar Guohong Cui Dopamine Neuron Challenge Test for early detection of Parkinson’s disease npj Parkinson's Disease |
| title | Dopamine Neuron Challenge Test for early detection of Parkinson’s disease |
| title_full | Dopamine Neuron Challenge Test for early detection of Parkinson’s disease |
| title_fullStr | Dopamine Neuron Challenge Test for early detection of Parkinson’s disease |
| title_full_unstemmed | Dopamine Neuron Challenge Test for early detection of Parkinson’s disease |
| title_short | Dopamine Neuron Challenge Test for early detection of Parkinson’s disease |
| title_sort | dopamine neuron challenge test for early detection of parkinson s disease |
| url | https://doi.org/10.1038/s41531-021-00261-z |
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