The Mechanism of DNA Methylation and miRNA in Breast Cancer
Breast cancer is the most prevalent cancer in the world. Currently, the main treatments for breast cancer are radiotherapy, chemotherapy, targeted therapy and surgery. The treatment measures for breast cancer depend on the molecular subtype. Thus, the exploration of the underlying molecular mechanis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9360 |
| _version_ | 1797597374754848768 |
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| author | Lingyuan Ma Chenyu Li Hanlin Yin Jiashu Huang Shenghao Yu Jin Zhao Yongxu Tang Min Yu Jie Lin Lei Ding Qinghua Cui |
| author_facet | Lingyuan Ma Chenyu Li Hanlin Yin Jiashu Huang Shenghao Yu Jin Zhao Yongxu Tang Min Yu Jie Lin Lei Ding Qinghua Cui |
| author_sort | Lingyuan Ma |
| collection | DOAJ |
| description | Breast cancer is the most prevalent cancer in the world. Currently, the main treatments for breast cancer are radiotherapy, chemotherapy, targeted therapy and surgery. The treatment measures for breast cancer depend on the molecular subtype. Thus, the exploration of the underlying molecular mechanisms and therapeutic targets for breast cancer remains a hotspot in research. In breast cancer, a high level of expression of DNMTs is highly correlated with poor prognosis, that is, the abnormal methylation of tumor suppressor genes usually promotes tumorigenesis and progression. MiRNAs, as non-coding RNAs, have been identified to play key roles in breast cancer. The aberrant methylation of miRNAs could lead to drug resistance during the aforementioned treatment. Therefore, the regulation of miRNA methylation might serve as a therapeutic target in breast cancer. In this paper, we reviewed studies on the regulatory mechanisms of miRNA and DNA methylation in breast cancer from the last decade, focusing on the promoter region of tumor suppressor miRNAs methylated by DNMTs and the highly expressed oncogenic miRNAs inhibited by DNMTs or activating TETs. |
| first_indexed | 2024-03-11T03:05:20Z |
| format | Article |
| id | doaj.art-144aa858dd92405cbdff666a868e0e76 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:20Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-144aa858dd92405cbdff666a868e0e762023-11-18T07:57:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411936010.3390/ijms24119360The Mechanism of DNA Methylation and miRNA in Breast CancerLingyuan Ma0Chenyu Li1Hanlin Yin2Jiashu Huang3Shenghao Yu4Jin Zhao5Yongxu Tang6Min Yu7Jie Lin8Lei Ding9Qinghua Cui10Lab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaLab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, ChinaBreast cancer is the most prevalent cancer in the world. Currently, the main treatments for breast cancer are radiotherapy, chemotherapy, targeted therapy and surgery. The treatment measures for breast cancer depend on the molecular subtype. Thus, the exploration of the underlying molecular mechanisms and therapeutic targets for breast cancer remains a hotspot in research. In breast cancer, a high level of expression of DNMTs is highly correlated with poor prognosis, that is, the abnormal methylation of tumor suppressor genes usually promotes tumorigenesis and progression. MiRNAs, as non-coding RNAs, have been identified to play key roles in breast cancer. The aberrant methylation of miRNAs could lead to drug resistance during the aforementioned treatment. Therefore, the regulation of miRNA methylation might serve as a therapeutic target in breast cancer. In this paper, we reviewed studies on the regulatory mechanisms of miRNA and DNA methylation in breast cancer from the last decade, focusing on the promoter region of tumor suppressor miRNAs methylated by DNMTs and the highly expressed oncogenic miRNAs inhibited by DNMTs or activating TETs.https://www.mdpi.com/1422-0067/24/11/9360breast cancerDNA methylationmiRNAdrug resistance |
| spellingShingle | Lingyuan Ma Chenyu Li Hanlin Yin Jiashu Huang Shenghao Yu Jin Zhao Yongxu Tang Min Yu Jie Lin Lei Ding Qinghua Cui The Mechanism of DNA Methylation and miRNA in Breast Cancer International Journal of Molecular Sciences breast cancer DNA methylation miRNA drug resistance |
| title | The Mechanism of DNA Methylation and miRNA in Breast Cancer |
| title_full | The Mechanism of DNA Methylation and miRNA in Breast Cancer |
| title_fullStr | The Mechanism of DNA Methylation and miRNA in Breast Cancer |
| title_full_unstemmed | The Mechanism of DNA Methylation and miRNA in Breast Cancer |
| title_short | The Mechanism of DNA Methylation and miRNA in Breast Cancer |
| title_sort | mechanism of dna methylation and mirna in breast cancer |
| topic | breast cancer DNA methylation miRNA drug resistance |
| url | https://www.mdpi.com/1422-0067/24/11/9360 |
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