Comeback of ketamine: resurfacing facts and dispelling myths
Initially known as CI-581, ketamine was first synthesized in 1962 as a replacement from phencyclidine. It has since been used as an anesthetic and analgesic. In addition, it has bronchodilating, sedative, and amnestic properties, preserving airway reflexes and sympathetic nervous system tone. Since...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Anesthesiologists
2021-04-01
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| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kja-20663.pdf |
| _version_ | 1818726177981857792 |
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| author | Abhijit Kumar Amit Kohli |
| author_facet | Abhijit Kumar Amit Kohli |
| author_sort | Abhijit Kumar |
| collection | DOAJ |
| description | Initially known as CI-581, ketamine was first synthesized in 1962 as a replacement from phencyclidine. It has since been used as an anesthetic and analgesic. In addition, it has bronchodilating, sedative, and amnestic properties, preserving airway reflexes and sympathetic nervous system tone. Since the discovery of ketamine, it has been a major topic of discussion due to controversies regarding its usage in particular sets of patients. In the past 50 years, despite its potential benefits, it is not commonly used because of concerns of “emergence phenomenon,” its use as a substance of abuse, and its systemic side effects. Since 2012, three World Health Organization reviews on ketamine have addressed its international control. Researchers have been studying this wonder drug for a decade worldwide. Many myths of ketamine regarding emergence phenomenon and its use in traumatic brain injury and open eye injury have been disproved in recent times. It is becoming popular in pre-hospital settings, critical care, emergency medicine, low-dose acute pain services, and adjuvant in regional anesthesia techniques. This review highlights the current consensus on the various applications of ketamine in the literature. |
| first_indexed | 2024-12-17T21:54:04Z |
| format | Article |
| id | doaj.art-144c0f6d7d784612af3523e099535579 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-17T21:54:04Z |
| publishDate | 2021-04-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-144c0f6d7d784612af3523e0995355792022-12-21T21:31:10ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632021-04-0174210311410.4097/kja.206638718Comeback of ketamine: resurfacing facts and dispelling mythsAbhijit Kumar0Amit Kohli1 Department of Anesthesiology, VMMC and Safdarjung Hospital, New Delhi, India Department of Anesthesiology, Maulana Azad Medical College, New Delhi, IndiaInitially known as CI-581, ketamine was first synthesized in 1962 as a replacement from phencyclidine. It has since been used as an anesthetic and analgesic. In addition, it has bronchodilating, sedative, and amnestic properties, preserving airway reflexes and sympathetic nervous system tone. Since the discovery of ketamine, it has been a major topic of discussion due to controversies regarding its usage in particular sets of patients. In the past 50 years, despite its potential benefits, it is not commonly used because of concerns of “emergence phenomenon,” its use as a substance of abuse, and its systemic side effects. Since 2012, three World Health Organization reviews on ketamine have addressed its international control. Researchers have been studying this wonder drug for a decade worldwide. Many myths of ketamine regarding emergence phenomenon and its use in traumatic brain injury and open eye injury have been disproved in recent times. It is becoming popular in pre-hospital settings, critical care, emergency medicine, low-dose acute pain services, and adjuvant in regional anesthesia techniques. This review highlights the current consensus on the various applications of ketamine in the literature.http://ekja.org/upload/pdf/kja-20663.pdfacuteantidepressantscancer painhallucinationsintracranial pressureintraocular pressureketaminepain clinicsstatus epilepticus |
| spellingShingle | Abhijit Kumar Amit Kohli Comeback of ketamine: resurfacing facts and dispelling myths Korean Journal of Anesthesiology acute antidepressants cancer pain hallucinations intracranial pressure intraocular pressure ketamine pain clinics status epilepticus |
| title | Comeback of ketamine: resurfacing facts and dispelling myths |
| title_full | Comeback of ketamine: resurfacing facts and dispelling myths |
| title_fullStr | Comeback of ketamine: resurfacing facts and dispelling myths |
| title_full_unstemmed | Comeback of ketamine: resurfacing facts and dispelling myths |
| title_short | Comeback of ketamine: resurfacing facts and dispelling myths |
| title_sort | comeback of ketamine resurfacing facts and dispelling myths |
| topic | acute antidepressants cancer pain hallucinations intracranial pressure intraocular pressure ketamine pain clinics status epilepticus |
| url | http://ekja.org/upload/pdf/kja-20663.pdf |
| work_keys_str_mv | AT abhijitkumar comebackofketamineresurfacingfactsanddispellingmyths AT amitkohli comebackofketamineresurfacingfactsanddispellingmyths |