Inhibition of bromodomain extraterminal histone readers alleviates skin fibrosis in experimental models of scleroderma

Inhibition of bromodomain extraterminal histone readers alleviates skin fibrosis in experimental models of scleroderma

Binding of the bromodomain and extraterminal domain proteins (BETs) to acetylated histone residues is critical for gene transcription. We sought to determine the antifibrotic efficacy and potential mechanisms of BET inhibition in systemic sclerosis (SSc). Blockade of BETs was done using a pan-BET in...

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Bibliographic Details
Main Authors: Sirapa Vichaikul, Mikel Gurrea-Rubio, M. Asif Amin, Phillip L. Campbell, Qi Wu, Megan N. Mattichak, William D. Brodie, Pamela J. Palisoc, Mustafa Ali, Sei Muraoka, Jeffrey H. Ruth, Ellen N. Model, Dallas M. Rohraff, Jonatan L. Hervoso, Yang Mao-Draayer, David A. Fox, Dinesh Khanna, Amr H. Sawalha, Pei-Suen Tsou
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-05-01
Series:JCI Insight
Subjects:
Autoimmunity
Online Access:https://doi.org/10.1172/jci.insight.150871

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