Structure-Activity Relationships of Holothuroid’s Triterpene Glycosides and Some In Silico Insights Obtained by Molecular Dynamics Study on the Mechanisms of Their Membranolytic Action

Structure-Activity Relationships of Holothuroid’s Triterpene Glycosides and Some In Silico Insights Obtained by Molecular Dynamics Study on the Mechanisms of Their Membranolytic Action

The article describes the structure-activity relationships (SAR) for a broad series of sea cucumber glycosides on different tumor cell lines and erythrocytes, and an in silico modulation of the interaction of selected glycosides from the sea cucumber <em>Eupentacta fraudatrix</em> with m...

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Bibliographic Details
Main Authors: Elena A. Zelepuga, Alexandra S. Silchenko, Sergey A. Avilov, Vladimir I. Kalinin
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Marine Drugs
Subjects:
triterpene glycosides
sea cucumber
membranolytic action
hemolytic
cytotoxic activity
molecular dynamic simulation
Online Access:https://www.mdpi.com/1660-3397/19/11/604

Internet

https://www.mdpi.com/1660-3397/19/11/604

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