Structure-Activity Relationships of Holothuroid’s Triterpene Glycosides and Some In Silico Insights Obtained by Molecular Dynamics Study on the Mechanisms of Their Membranolytic Action

Structure-Activity Relationships of Holothuroid’s Triterpene Glycosides and Some In Silico Insights Obtained by Molecular Dynamics Study on the Mechanisms of Their Membranolytic Action

The article describes the structure-activity relationships (SAR) for a broad series of sea cucumber glycosides on different tumor cell lines and erythrocytes, and an in silico modulation of the interaction of selected glycosides from the sea cucumber <em>Eupentacta fraudatrix</em> with m...

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Bibliographic Details
Main Authors:	Elena A. Zelepuga, Alexandra S. Silchenko, Sergey A. Avilov, Vladimir I. Kalinin
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Series:	Marine Drugs
Subjects:	triterpene glycosides sea cucumber membranolytic action hemolytic cytotoxic activity molecular dynamic simulation
Online Access:	https://www.mdpi.com/1660-3397/19/11/604

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