Effect of alcoholic beverages on progeny and reproduction of mice
ABSTRACT Alcohol is the most commonly consumed substance in the world. The objective of this study was to evaluate the influence of alcoholic beverages on male reproduction and possible alterations in their offspring. The mice were divided into 4 groups: beer, wine, cachaça (a type of sugarcane rum)...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2018-03-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400612&lng=en&tlng=en |
| _version_ | 1818393034249732096 |
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| author | Fernanda Dias Figueiro Ana Clara Cerato Bispo Karla Lorena Guarido Priscila Marianno Gabriel de Araújo Costa Helena Kaminami Morimoto Maria José Sparça Salles |
| author_facet | Fernanda Dias Figueiro Ana Clara Cerato Bispo Karla Lorena Guarido Priscila Marianno Gabriel de Araújo Costa Helena Kaminami Morimoto Maria José Sparça Salles |
| author_sort | Fernanda Dias Figueiro |
| collection | DOAJ |
| description | ABSTRACT Alcohol is the most commonly consumed substance in the world. The objective of this study was to evaluate the influence of alcoholic beverages on male reproduction and possible alterations in their offspring. The mice were divided into 4 groups: beer, wine, cachaça (a type of sugarcane rum), with ethanol concentrations of 1.9 g/kg, and control group treated with PBS. The treatment period was 35 days. The animals which received cachaça, demonstrated significant weight loss in the testes and epididymis. The alcoholic beverages promoted significant testosterone level and fertilization index diminution, and morphological alterations in the spermatozoa. The beer group presented decreased implantation sites and a high frequency of dominant lethal. The number of reabsorptions in the wine group was increased. The fermented beverages presented higher potential to induce visceral malformations, while the cachaça caused fetal skeletal malformations. The cachaça treated group presented a negative impact on semen quality and fertilization potential. The treatment with different alcoholic beverages, during spermatogenesis, demonstrated contrasting degrees of induction of toxic effects, interfering in a general aspect in male reproductive performance, fetal viability during intrauterine life, and birth defects. From the data, it is possible to infer that the distillated beverage caused more harmful effects to reproduction in this study. |
| first_indexed | 2024-12-14T05:38:53Z |
| format | Article |
| id | doaj.art-1451fe0e958e459f898b1fe051f196ea |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-14T05:38:53Z |
| publishDate | 2018-03-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-1451fe0e958e459f898b1fe051f196ea2022-12-21T23:15:05ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902018-03-0153410.1590/s2175-97902017000417141S1984-82502017000400612Effect of alcoholic beverages on progeny and reproduction of miceFernanda Dias FigueiroAna Clara Cerato BispoKarla Lorena GuaridoPriscila MariannoGabriel de Araújo CostaHelena Kaminami MorimotoMaria José Sparça SallesABSTRACT Alcohol is the most commonly consumed substance in the world. The objective of this study was to evaluate the influence of alcoholic beverages on male reproduction and possible alterations in their offspring. The mice were divided into 4 groups: beer, wine, cachaça (a type of sugarcane rum), with ethanol concentrations of 1.9 g/kg, and control group treated with PBS. The treatment period was 35 days. The animals which received cachaça, demonstrated significant weight loss in the testes and epididymis. The alcoholic beverages promoted significant testosterone level and fertilization index diminution, and morphological alterations in the spermatozoa. The beer group presented decreased implantation sites and a high frequency of dominant lethal. The number of reabsorptions in the wine group was increased. The fermented beverages presented higher potential to induce visceral malformations, while the cachaça caused fetal skeletal malformations. The cachaça treated group presented a negative impact on semen quality and fertilization potential. The treatment with different alcoholic beverages, during spermatogenesis, demonstrated contrasting degrees of induction of toxic effects, interfering in a general aspect in male reproductive performance, fetal viability during intrauterine life, and birth defects. From the data, it is possible to infer that the distillated beverage caused more harmful effects to reproduction in this study.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400612&lng=en&tlng=enAlcoholic beverages/analysisWine/adverse effectsBeer/adverse effectsCachaça/adverse effectsReproduction/drugs effects |
| spellingShingle | Fernanda Dias Figueiro Ana Clara Cerato Bispo Karla Lorena Guarido Priscila Marianno Gabriel de Araújo Costa Helena Kaminami Morimoto Maria José Sparça Salles Effect of alcoholic beverages on progeny and reproduction of mice Brazilian Journal of Pharmaceutical Sciences Alcoholic beverages/analysis Wine/adverse effects Beer/adverse effects Cachaça/adverse effects Reproduction/drugs effects |
| title | Effect of alcoholic beverages on progeny and reproduction of mice |
| title_full | Effect of alcoholic beverages on progeny and reproduction of mice |
| title_fullStr | Effect of alcoholic beverages on progeny and reproduction of mice |
| title_full_unstemmed | Effect of alcoholic beverages on progeny and reproduction of mice |
| title_short | Effect of alcoholic beverages on progeny and reproduction of mice |
| title_sort | effect of alcoholic beverages on progeny and reproduction of mice |
| topic | Alcoholic beverages/analysis Wine/adverse effects Beer/adverse effects Cachaça/adverse effects Reproduction/drugs effects |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400612&lng=en&tlng=en |
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