Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus
ObjectiveTo investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies.Subjects and methodsThis study included 200 pregnant women. 25-hydroxyvitamin D3(25(OH)D3) and MPV...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Brazilian Society of Endocrinology and Metabolism
2015-07-01
|
| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000500448&lng=en&tlng=en |
| _version_ | 1819047107761274880 |
|---|---|
| author | Esra Bahar Gur Muammer Karadeniz Mine Genc Fatma Eskicioglu Murat Yalcin Irem Hepyilmaz Serkan Guclu |
| author_facet | Esra Bahar Gur Muammer Karadeniz Mine Genc Fatma Eskicioglu Murat Yalcin Irem Hepyilmaz Serkan Guclu |
| author_sort | Esra Bahar Gur |
| collection | DOAJ |
| description | ObjectiveTo investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies.Subjects and methodsThis study included 200 pregnant women. 25-hydroxyvitamin D3(25(OH)D3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D3 level in different MPV percentile (≤ 50, 50-75, 75-90, ≥ 90 percentile) and MPV value in different 25(OH)D3 level (≤ 10, 10-20, ≥ 20 ng/mL) were calculated.ResultsLow 25(OH)D3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D3 level in GMD group (p = 0.04). The optimal 25(OH)D3 cut off point for predicting future cardiovascular risk was 10.4 ng/ mL (area under curve (AUC) = 0.58).ConclusionsVitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM. |
| first_indexed | 2024-12-21T10:55:06Z |
| format | Article |
| id | doaj.art-1453098058c74886bd839f20ecd2228e |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-21T10:55:06Z |
| publishDate | 2015-07-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-1453098058c74886bd839f20ecd2228e2022-12-21T19:06:31ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922015-07-0159544845410.1590/2359-3997000000063S2359-39972015000500448Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitusEsra Bahar GurMuammer KaradenizMine GencFatma EskiciogluMurat YalcinIrem HepyilmazSerkan GucluObjectiveTo investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies.Subjects and methodsThis study included 200 pregnant women. 25-hydroxyvitamin D3(25(OH)D3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D3 level in different MPV percentile (≤ 50, 50-75, 75-90, ≥ 90 percentile) and MPV value in different 25(OH)D3 level (≤ 10, 10-20, ≥ 20 ng/mL) were calculated.ResultsLow 25(OH)D3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D3 level in GMD group (p = 0.04). The optimal 25(OH)D3 cut off point for predicting future cardiovascular risk was 10.4 ng/ mL (area under curve (AUC) = 0.58).ConclusionsVitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000500448&lng=en&tlng=enGestational diabetes mellitusvitamin D deficiencymean platelet volume |
| spellingShingle | Esra Bahar Gur Muammer Karadeniz Mine Genc Fatma Eskicioglu Murat Yalcin Irem Hepyilmaz Serkan Guclu Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus Archives of Endocrinology and Metabolism Gestational diabetes mellitus vitamin D deficiency mean platelet volume |
| title | Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus |
| title_full | Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus |
| title_fullStr | Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus |
| title_full_unstemmed | Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus |
| title_short | Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus |
| title_sort | relationship between mean platelet volume and vitamin d deficiency in gestational diabetes mellitus |
| topic | Gestational diabetes mellitus vitamin D deficiency mean platelet volume |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000500448&lng=en&tlng=en |
| work_keys_str_mv | AT esrabahargur relationshipbetweenmeanplateletvolumeandvitaminddeficiencyingestationaldiabetesmellitus AT muammerkaradeniz relationshipbetweenmeanplateletvolumeandvitaminddeficiencyingestationaldiabetesmellitus AT minegenc relationshipbetweenmeanplateletvolumeandvitaminddeficiencyingestationaldiabetesmellitus AT fatmaeskicioglu relationshipbetweenmeanplateletvolumeandvitaminddeficiencyingestationaldiabetesmellitus AT muratyalcin relationshipbetweenmeanplateletvolumeandvitaminddeficiencyingestationaldiabetesmellitus AT iremhepyilmaz relationshipbetweenmeanplateletvolumeandvitaminddeficiencyingestationaldiabetesmellitus AT serkanguclu relationshipbetweenmeanplateletvolumeandvitaminddeficiencyingestationaldiabetesmellitus |