Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen <i>Streptococcus suis</i>
<i>Streptococcus suis</i> is a zoonotic pathogen causing important economic losses in swine production. The most commonly used antibiotics in swine industry are tetracyclines, beta-lactams, and macrolides. Resistance to these antibiotics has already been observed worldwide (reaching high...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/8/1765 |
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| author | Manon Dechêne-Tempier Corinne Marois-Créhan Virginie Libante Eric Jouy Nathalie Leblond-Bourget Sophie Payot |
| author_facet | Manon Dechêne-Tempier Corinne Marois-Créhan Virginie Libante Eric Jouy Nathalie Leblond-Bourget Sophie Payot |
| author_sort | Manon Dechêne-Tempier |
| collection | DOAJ |
| description | <i>Streptococcus suis</i> is a zoonotic pathogen causing important economic losses in swine production. The most commonly used antibiotics in swine industry are tetracyclines, beta-lactams, and macrolides. Resistance to these antibiotics has already been observed worldwide (reaching high rates for macrolides and tetracyclines) as well as resistance to aminoglycosides, fluoroquinolones, amphenicols, and glycopeptides. Most of the resistance mechanisms are encoded by antibiotic resistance genes, and a large part are carried by mobile genetic elements (MGEs) that can be transferred through horizontal gene transfer. This review provides an update of the resistance genes, their combination in multidrug isolates, and their localization on MGEs in <i>S. suis.</i> It also includes an overview of the contribution of biofilm to antimicrobial resistance in this bacterial species. The identification of resistance genes and study of their localization in <i>S. suis</i> as well as the environmental factors that can modulate their dissemination appear essential in order to decipher the role of this bacterium as a reservoir of antibiotic genes for other species. |
| first_indexed | 2024-03-10T08:33:51Z |
| format | Article |
| id | doaj.art-1454ae99bb9049a3b0a862cb5fc77b18 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T08:33:51Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-1454ae99bb9049a3b0a862cb5fc77b182023-11-22T08:48:32ZengMDPI AGMicroorganisms2076-26072021-08-0198176510.3390/microorganisms9081765Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen <i>Streptococcus suis</i>Manon Dechêne-Tempier0Corinne Marois-Créhan1Virginie Libante2Eric Jouy3Nathalie Leblond-Bourget4Sophie Payot5Anses Laboratoire de Ploufragan-Plouzané-Niort, Unité Mycoplasmologie, Bactériologie et Antibiorésistance, F-22440 Ploufragan, FranceAnses Laboratoire de Ploufragan-Plouzané-Niort, Unité Mycoplasmologie, Bactériologie et Antibiorésistance, F-22440 Ploufragan, FranceUniversité de Lorraine, INRAE, DynAMic, F-54000 Nancy, FranceAnses Laboratoire de Ploufragan-Plouzané-Niort, Unité Mycoplasmologie, Bactériologie et Antibiorésistance, F-22440 Ploufragan, FranceUniversité de Lorraine, INRAE, DynAMic, F-54000 Nancy, FranceUniversité de Lorraine, INRAE, DynAMic, F-54000 Nancy, France<i>Streptococcus suis</i> is a zoonotic pathogen causing important economic losses in swine production. The most commonly used antibiotics in swine industry are tetracyclines, beta-lactams, and macrolides. Resistance to these antibiotics has already been observed worldwide (reaching high rates for macrolides and tetracyclines) as well as resistance to aminoglycosides, fluoroquinolones, amphenicols, and glycopeptides. Most of the resistance mechanisms are encoded by antibiotic resistance genes, and a large part are carried by mobile genetic elements (MGEs) that can be transferred through horizontal gene transfer. This review provides an update of the resistance genes, their combination in multidrug isolates, and their localization on MGEs in <i>S. suis.</i> It also includes an overview of the contribution of biofilm to antimicrobial resistance in this bacterial species. The identification of resistance genes and study of their localization in <i>S. suis</i> as well as the environmental factors that can modulate their dissemination appear essential in order to decipher the role of this bacterium as a reservoir of antibiotic genes for other species.https://www.mdpi.com/2076-2607/9/8/1765<i>Streptococcus suis</i>antibiotic resistancemechanismsresistance geneshorizontal gene transfercompetence |
| spellingShingle | Manon Dechêne-Tempier Corinne Marois-Créhan Virginie Libante Eric Jouy Nathalie Leblond-Bourget Sophie Payot Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen <i>Streptococcus suis</i> Microorganisms <i>Streptococcus suis</i> antibiotic resistance mechanisms resistance genes horizontal gene transfer competence |
| title | Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen <i>Streptococcus suis</i> |
| title_full | Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen <i>Streptococcus suis</i> |
| title_fullStr | Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen <i>Streptococcus suis</i> |
| title_full_unstemmed | Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen <i>Streptococcus suis</i> |
| title_short | Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen <i>Streptococcus suis</i> |
| title_sort | update on the mechanisms of antibiotic resistance and the mobile resistome in the emerging zoonotic pathogen i streptococcus suis i |
| topic | <i>Streptococcus suis</i> antibiotic resistance mechanisms resistance genes horizontal gene transfer competence |
| url | https://www.mdpi.com/2076-2607/9/8/1765 |
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