A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems
Air pollution is one of the significant environmental risks known as the cause of premature deaths. It has deleterious effects on human health, including deteriorating respiratory, cardiovascular, nervous, and endocrine functions. Exposure to air pollution stimulates reactive oxygen species (ROS) pr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
|
| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2023/4961487 |
| _version_ | 1797903007235440640 |
|---|---|
| author | Dwi Aris Agung Nugrahaningsih Hevi Wihadmadyatami Sitarina Widyarini Rahmi Ayu Wijayaningsih |
| author_facet | Dwi Aris Agung Nugrahaningsih Hevi Wihadmadyatami Sitarina Widyarini Rahmi Ayu Wijayaningsih |
| author_sort | Dwi Aris Agung Nugrahaningsih |
| collection | DOAJ |
| description | Air pollution is one of the significant environmental risks known as the cause of premature deaths. It has deleterious effects on human health, including deteriorating respiratory, cardiovascular, nervous, and endocrine functions. Exposure to air pollution stimulates reactive oxygen species (ROS) production in the body, which can further cause oxidative stress. Antioxidant enzymes, such as glutathione S-transferase mu 1 (GSTM1), are essential to prevent oxidative stress development by neutralizing excess oxidants. When the antioxidant enzyme function is lacking, ROS can accumulate and, thus, cause oxidative stress. Genetic variation studies from different countries show that GSTM1 null genotype dominates the GSTM1 genotype in the population. However, the impact of the GSTM1 null genotype in modifying the association between air pollution and health problem is not yet clear. This study will elaborate on GSTM1’s null genotype role in modifying the relationship between air pollution and health problems. |
| first_indexed | 2024-04-10T09:26:09Z |
| format | Article |
| id | doaj.art-1454e9b3826644feb840f93083a6a82b |
| institution | Directory Open Access Journal |
| issn | 2314-4378 |
| language | English |
| last_indexed | 2024-04-10T09:26:09Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj.art-1454e9b3826644feb840f93083a6a82b2023-02-20T01:57:44ZengHindawi LimitedInternational Journal of Genomics2314-43782023-01-01202310.1155/2023/4961487A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health ProblemsDwi Aris Agung Nugrahaningsih0Hevi Wihadmadyatami1Sitarina Widyarini2Rahmi Ayu Wijayaningsih3Department of Pharmacology and TherapyDepartment of AnatomyDepartment of PathologyMaster of Biomedical Science ProgramAir pollution is one of the significant environmental risks known as the cause of premature deaths. It has deleterious effects on human health, including deteriorating respiratory, cardiovascular, nervous, and endocrine functions. Exposure to air pollution stimulates reactive oxygen species (ROS) production in the body, which can further cause oxidative stress. Antioxidant enzymes, such as glutathione S-transferase mu 1 (GSTM1), are essential to prevent oxidative stress development by neutralizing excess oxidants. When the antioxidant enzyme function is lacking, ROS can accumulate and, thus, cause oxidative stress. Genetic variation studies from different countries show that GSTM1 null genotype dominates the GSTM1 genotype in the population. However, the impact of the GSTM1 null genotype in modifying the association between air pollution and health problem is not yet clear. This study will elaborate on GSTM1’s null genotype role in modifying the relationship between air pollution and health problems.http://dx.doi.org/10.1155/2023/4961487 |
| spellingShingle | Dwi Aris Agung Nugrahaningsih Hevi Wihadmadyatami Sitarina Widyarini Rahmi Ayu Wijayaningsih A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems International Journal of Genomics |
| title | A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems |
| title_full | A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems |
| title_fullStr | A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems |
| title_full_unstemmed | A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems |
| title_short | A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems |
| title_sort | review of the gstm1 null genotype modifies the association between air pollutant exposure and health problems |
| url | http://dx.doi.org/10.1155/2023/4961487 |
| work_keys_str_mv | AT dwiarisagungnugrahaningsih areviewofthegstm1nullgenotypemodifiestheassociationbetweenairpollutantexposureandhealthproblems AT heviwihadmadyatami areviewofthegstm1nullgenotypemodifiestheassociationbetweenairpollutantexposureandhealthproblems AT sitarinawidyarini areviewofthegstm1nullgenotypemodifiestheassociationbetweenairpollutantexposureandhealthproblems AT rahmiayuwijayaningsih areviewofthegstm1nullgenotypemodifiestheassociationbetweenairpollutantexposureandhealthproblems AT dwiarisagungnugrahaningsih reviewofthegstm1nullgenotypemodifiestheassociationbetweenairpollutantexposureandhealthproblems AT heviwihadmadyatami reviewofthegstm1nullgenotypemodifiestheassociationbetweenairpollutantexposureandhealthproblems AT sitarinawidyarini reviewofthegstm1nullgenotypemodifiestheassociationbetweenairpollutantexposureandhealthproblems AT rahmiayuwijayaningsih reviewofthegstm1nullgenotypemodifiestheassociationbetweenairpollutantexposureandhealthproblems |