Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study
SARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism. Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The lipid profile is a less robust biochemical marker than apolipoproteins, components of lipoproteins. However, the association of ap...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4605 |
| _version_ | 1797615135944081408 |
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| author | Floran Begue Kévin Chemello Bryan Veeren Brice Lortat-Jacob Alexy Tran-Dinh Nathalie Zappella Aurelie Snauwaert Tiphaine Robert Philippe Rondeau Marie Lagrange-Xelot Philippe Montravers David Couret Sébastien Tanaka Olivier Meilhac |
| author_facet | Floran Begue Kévin Chemello Bryan Veeren Brice Lortat-Jacob Alexy Tran-Dinh Nathalie Zappella Aurelie Snauwaert Tiphaine Robert Philippe Rondeau Marie Lagrange-Xelot Philippe Montravers David Couret Sébastien Tanaka Olivier Meilhac |
| author_sort | Floran Begue |
| collection | DOAJ |
| description | SARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism. Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The lipid profile is a less robust biochemical marker than apolipoproteins, components of lipoproteins. However, the association of apolipoprotein levels during COVID-19 is not well described and understood. The objective of our study is to measure plasma levels of 14 apolipoproteins in patients with COVID-19 and to evaluate the relationships between apolipoprotein levels, severity factors and patient outcomes. From November to March 2021, 44 patients were recruited on admission to the intensive care unit because of COVID-19. Fourteen apolipoproteins and LCAT were measured by LC-MS/MS in plasma of 44 COVID-19 patients on admission to the ICU and 44 healthy control subjects. Absolute apolipoprotein concentrations were compared between COVID-19 patients and controls. Plasma apolipoproteins (Apo) A (I, II, IV), C(I, II), D, H, J and M and LCAT were lower in COVID-19 patients, whereas Apo E was higher. COVID-19 severity factors such as PaO2/FiO2 ratio, SO-FA score and CRP were correlated with certain apolipoproteins. Lower Apo B100 and LCAT levels were observed in non-survivors of COVID-19 versus survivors. To conclude, in this study, lipid and apolipoprotein profiles are altered in COVID-19 patients. Low Apo B100 and LCAT levels may be predictive of non-survival in COVID-19 patients. |
| first_indexed | 2024-03-11T07:22:15Z |
| format | Article |
| id | doaj.art-1458570193934b04a662248c0455ef9a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:15Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1458570193934b04a662248c0455ef9a2023-11-17T07:50:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245460510.3390/ijms24054605Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort StudyFloran Begue0Kévin Chemello1Bryan Veeren2Brice Lortat-Jacob3Alexy Tran-Dinh4Nathalie Zappella5Aurelie Snauwaert6Tiphaine Robert7Philippe Rondeau8Marie Lagrange-Xelot9Philippe Montravers10David Couret11Sébastien Tanaka12Olivier Meilhac13INSERM, UMR 1188 Diabète Athérothrombose Réunion Océan Indien (DéTROI), Université de La Réunion, 97410 Saint-Pierre de La Réunion, FranceINSERM, UMR 1188 Diabète Athérothrombose Réunion Océan Indien (DéTROI), Université de La Réunion, 97410 Saint-Pierre de La Réunion, FranceINSERM, UMR 1188 Diabète Athérothrombose Réunion Océan Indien (DéTROI), Université de La Réunion, 97410 Saint-Pierre de La Réunion, FranceAssistance Publique—Hôpitaux de Paris (AP-HP), Department of Anesthesiology and Critical Care Medicine, Assistance, Bichat-Claude Bernard Hospital, 75018 Paris, FranceAssistance Publique—Hôpitaux de Paris (AP-HP), Department of Anesthesiology and Critical Care Medicine, Assistance, Bichat-Claude Bernard Hospital, 75018 Paris, FranceAssistance Publique—Hôpitaux de Paris (AP-HP), Department of Anesthesiology and Critical Care Medicine, Assistance, Bichat-Claude Bernard Hospital, 75018 Paris, FranceAssistance Publique—Hôpitaux de Paris (AP-HP), Department of Anesthesiology and Critical Care Medicine, Assistance, Bichat-Claude Bernard Hospital, 75018 Paris, FranceAssistance Publique—Hôpitaux de Paris (AP-HP), Biochemistry Department, Bichat-Claude Bernard Hospital, 75018 Paris, FranceINSERM, UMR 1188 Diabète Athérothrombose Réunion Océan Indien (DéTROI), Université de La Réunion, 97410 Saint-Pierre de La Réunion, FranceCHU de La Réunion, 97400 Saint-Denis, FranceAssistance Publique—Hôpitaux de Paris (AP-HP), Department of Anesthesiology and Critical Care Medicine, Assistance, Bichat-Claude Bernard Hospital, 75018 Paris, FranceINSERM, UMR 1188 Diabète Athérothrombose Réunion Océan Indien (DéTROI), Université de La Réunion, 97410 Saint-Pierre de La Réunion, FranceINSERM, UMR 1188 Diabète Athérothrombose Réunion Océan Indien (DéTROI), Université de La Réunion, 97410 Saint-Pierre de La Réunion, FranceINSERM, UMR 1188 Diabète Athérothrombose Réunion Océan Indien (DéTROI), Université de La Réunion, 97410 Saint-Pierre de La Réunion, FranceSARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism. Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The lipid profile is a less robust biochemical marker than apolipoproteins, components of lipoproteins. However, the association of apolipoprotein levels during COVID-19 is not well described and understood. The objective of our study is to measure plasma levels of 14 apolipoproteins in patients with COVID-19 and to evaluate the relationships between apolipoprotein levels, severity factors and patient outcomes. From November to March 2021, 44 patients were recruited on admission to the intensive care unit because of COVID-19. Fourteen apolipoproteins and LCAT were measured by LC-MS/MS in plasma of 44 COVID-19 patients on admission to the ICU and 44 healthy control subjects. Absolute apolipoprotein concentrations were compared between COVID-19 patients and controls. Plasma apolipoproteins (Apo) A (I, II, IV), C(I, II), D, H, J and M and LCAT were lower in COVID-19 patients, whereas Apo E was higher. COVID-19 severity factors such as PaO2/FiO2 ratio, SO-FA score and CRP were correlated with certain apolipoproteins. Lower Apo B100 and LCAT levels were observed in non-survivors of COVID-19 versus survivors. To conclude, in this study, lipid and apolipoprotein profiles are altered in COVID-19 patients. Low Apo B100 and LCAT levels may be predictive of non-survival in COVID-19 patients.https://www.mdpi.com/1422-0067/24/5/4605COVID-19HDL-CLDL-Capolipoproteinmass spectrometryoutcome |
| spellingShingle | Floran Begue Kévin Chemello Bryan Veeren Brice Lortat-Jacob Alexy Tran-Dinh Nathalie Zappella Aurelie Snauwaert Tiphaine Robert Philippe Rondeau Marie Lagrange-Xelot Philippe Montravers David Couret Sébastien Tanaka Olivier Meilhac Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study International Journal of Molecular Sciences COVID-19 HDL-C LDL-C apolipoprotein mass spectrometry outcome |
| title | Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study |
| title_full | Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study |
| title_fullStr | Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study |
| title_full_unstemmed | Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study |
| title_short | Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study |
| title_sort | plasma apolipoprotein concentrations are highly altered in severe intensive care unit covid 19 patients preliminary results from the lipicor cohort study |
| topic | COVID-19 HDL-C LDL-C apolipoprotein mass spectrometry outcome |
| url | https://www.mdpi.com/1422-0067/24/5/4605 |
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