Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery

Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery

MbtI from <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) is a Mg<sup>2+</sup>-dependent salicylate synthase, belonging to the chorismate-utilizing enzyme (CUE) family. As a fundamental player in iron acquisition, MbtI promotes the survival and pathogenicity of <...

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Bibliographic Details
Main Authors: Matteo Mori, Stefania Villa, Laurent R. Chiarelli, Fiorella Meneghetti, Marco Bellinzoni
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
<i>Mycobacterium tuberculosis</i>
salicylate synthase
siderophore
iron
co-crystal structure
anti-virulence therapy
Online Access:https://www.mdpi.com/1424-8247/16/11/1559

Internet

https://www.mdpi.com/1424-8247/16/11/1559

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