FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes
Adipocytes not only function as energy depots but also secrete numerous adipokines that regulate multiple metabolic processes, including lipid homeostasis. Dysregulation of lipid homeostasis, which often leads to adipocyte hypertrophy and/or ectopic lipid deposition in non-adipocyte cells such as mu...
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.645400/full |
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| author | Yu-Qing Lv Yu-Qing Lv Qhaweni Dhlamini Chengshui Chen Xiaokun Li Saverio Bellusci Saverio Bellusci Jin-San Zhang Jin-San Zhang |
| author_facet | Yu-Qing Lv Yu-Qing Lv Qhaweni Dhlamini Chengshui Chen Xiaokun Li Saverio Bellusci Saverio Bellusci Jin-San Zhang Jin-San Zhang |
| author_sort | Yu-Qing Lv |
| collection | DOAJ |
| description | Adipocytes not only function as energy depots but also secrete numerous adipokines that regulate multiple metabolic processes, including lipid homeostasis. Dysregulation of lipid homeostasis, which often leads to adipocyte hypertrophy and/or ectopic lipid deposition in non-adipocyte cells such as muscle and liver, is linked to the development of insulin resistance. Similarly, an altered secretion profile of adipokines or imbalance between calorie intake and energy expenditure is associated with obesity, among other related metabolic disorders. In lungs, lipid-laden adipocyte-like cells known as lipofibroblasts share numerous developmental and functional similarities with adipocytes, and similarly influence alveolar lipid homeostasis by facilitating pulmonary surfactant production. Unsurprisingly, disruption in alveolar lipid homeostasis may propagate several chronic inflammatory disorders of the lung. Given the numerous similarities between the two cell types, dissecting the molecular mechanisms underlying adipocyte development and function will offer valuable insights that may be applied to, at least, some aspects of lipofibroblast biology in normal and diseased lungs. FGF10, a major ligand for FGFR2b, is a multifunctional growth factor that is indispensable for several biological processes, including development of various organs and tissues such as the lung and WAT. Moreover, accumulating evidence strongly implicates FGF10 in several key aspects of adipogenesis as well as lipofibroblast formation and maintenance, and as a potential player in adipocyte metabolism. This review summarizes our current understanding of the role of FGF10 in adipocytes, while attempting to derive insights on the existing literature and extrapolate the knowledge to pulmonary lipofibroblasts. |
| first_indexed | 2024-12-18T00:47:15Z |
| format | Article |
| id | doaj.art-145c7302db9f4d7a93d9c3e7ddba3aee |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-18T00:47:15Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-145c7302db9f4d7a93d9c3e7ddba3aee2022-12-21T21:26:45ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-05-01910.3389/fcell.2021.645400645400FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the AdipocytesYu-Qing Lv0Yu-Qing Lv1Qhaweni Dhlamini2Chengshui Chen3Xiaokun Li4Saverio Bellusci5Saverio Bellusci6Jin-San Zhang7Jin-San Zhang8Key Laboratory of Interventional Pulmonology of Zhejiang Province, Center for Precision Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaInternational Collaborative Center on Growth Factor Research, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, ChinaInternational Collaborative Center on Growth Factor Research, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, Center for Precision Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaInternational Collaborative Center on Growth Factor Research, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, Center for Precision Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaCardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, GermanyKey Laboratory of Interventional Pulmonology of Zhejiang Province, Center for Precision Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaInternational Collaborative Center on Growth Factor Research, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, ChinaAdipocytes not only function as energy depots but also secrete numerous adipokines that regulate multiple metabolic processes, including lipid homeostasis. Dysregulation of lipid homeostasis, which often leads to adipocyte hypertrophy and/or ectopic lipid deposition in non-adipocyte cells such as muscle and liver, is linked to the development of insulin resistance. Similarly, an altered secretion profile of adipokines or imbalance between calorie intake and energy expenditure is associated with obesity, among other related metabolic disorders. In lungs, lipid-laden adipocyte-like cells known as lipofibroblasts share numerous developmental and functional similarities with adipocytes, and similarly influence alveolar lipid homeostasis by facilitating pulmonary surfactant production. Unsurprisingly, disruption in alveolar lipid homeostasis may propagate several chronic inflammatory disorders of the lung. Given the numerous similarities between the two cell types, dissecting the molecular mechanisms underlying adipocyte development and function will offer valuable insights that may be applied to, at least, some aspects of lipofibroblast biology in normal and diseased lungs. FGF10, a major ligand for FGFR2b, is a multifunctional growth factor that is indispensable for several biological processes, including development of various organs and tissues such as the lung and WAT. Moreover, accumulating evidence strongly implicates FGF10 in several key aspects of adipogenesis as well as lipofibroblast formation and maintenance, and as a potential player in adipocyte metabolism. This review summarizes our current understanding of the role of FGF10 in adipocytes, while attempting to derive insights on the existing literature and extrapolate the knowledge to pulmonary lipofibroblasts.https://www.frontiersin.org/articles/10.3389/fcell.2021.645400/fullFGF10adipocytesadipocyte-like cellsstem celllipofibroblastmyofibroblast |
| spellingShingle | Yu-Qing Lv Yu-Qing Lv Qhaweni Dhlamini Chengshui Chen Xiaokun Li Saverio Bellusci Saverio Bellusci Jin-San Zhang Jin-San Zhang FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes Frontiers in Cell and Developmental Biology FGF10 adipocytes adipocyte-like cells stem cell lipofibroblast myofibroblast |
| title | FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes |
| title_full | FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes |
| title_fullStr | FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes |
| title_full_unstemmed | FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes |
| title_short | FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes |
| title_sort | fgf10 and lipofibroblasts in lung homeostasis and disease insights gained from the adipocytes |
| topic | FGF10 adipocytes adipocyte-like cells stem cell lipofibroblast myofibroblast |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.645400/full |
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