Microbiota and Obesity: Where Are We Now?
Genetic and environmental factors are underlying causes of obesity and other metabolic diseases, so it is therefore difficult to find suitable and effective medical treatments. However, without a doubt, the gut microbiota—and also the bacteria present in the oral cavity—act as key factors in the dev...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/9/12/415 |
| _version_ | 1827701520036003840 |
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| author | Andrea Ballini Salvatore Scacco Mariarosaria Boccellino Luigi Santacroce Roberto Arrigoni |
| author_facet | Andrea Ballini Salvatore Scacco Mariarosaria Boccellino Luigi Santacroce Roberto Arrigoni |
| author_sort | Andrea Ballini |
| collection | DOAJ |
| description | Genetic and environmental factors are underlying causes of obesity and other metabolic diseases, so it is therefore difficult to find suitable and effective medical treatments. However, without a doubt, the gut microbiota—and also the bacteria present in the oral cavity—act as key factors in the development of these pathologies, yet the mechanisms have not been fully described. Certainly, a more detailed knowledge of the structure of the microbiota—composition, intra- and inter-species relationships, metabolic functions—could be of great help in counteracting the onset of obesity. Identifying key bacterial species will allow us to create a database of “healthy” bacteria, making it possible to manipulate the bacterial community according to metabolic and clinical needs. Targeting gut microbiota in clinical care as treatment for obesity and health-related complications—even just for weight loss has become a real possibility. In this topical review we provide an overview of the role of the microbiota on host energy homeostasis and obesity-related metabolic diseases, therefore addressing the therapeutic potential of novel and existing strategies (impact of nutrition/dietary modulation, and fecal microbiota transplantation) in the treatment of metabolic disease. |
| first_indexed | 2024-03-10T14:34:37Z |
| format | Article |
| id | doaj.art-145e14a79fe04398ad453f9f8167ff48 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T14:34:37Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-145e14a79fe04398ad453f9f8167ff482023-11-20T22:14:06ZengMDPI AGBiology2079-77372020-11-0191241510.3390/biology9120415Microbiota and Obesity: Where Are We Now?Andrea Ballini0Salvatore Scacco1Mariarosaria Boccellino2Luigi Santacroce3Roberto Arrigoni4Department of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario, University of Bari “Aldo Moro”, 70125 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyMicrobiology and Virology Laboratory, Ionian Department, Policlinico University Hospital, University of Bari “Aldo Moro”, 70124 Bari, ItalyCNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), 70124 Bari, ItalyGenetic and environmental factors are underlying causes of obesity and other metabolic diseases, so it is therefore difficult to find suitable and effective medical treatments. However, without a doubt, the gut microbiota—and also the bacteria present in the oral cavity—act as key factors in the development of these pathologies, yet the mechanisms have not been fully described. Certainly, a more detailed knowledge of the structure of the microbiota—composition, intra- and inter-species relationships, metabolic functions—could be of great help in counteracting the onset of obesity. Identifying key bacterial species will allow us to create a database of “healthy” bacteria, making it possible to manipulate the bacterial community according to metabolic and clinical needs. Targeting gut microbiota in clinical care as treatment for obesity and health-related complications—even just for weight loss has become a real possibility. In this topical review we provide an overview of the role of the microbiota on host energy homeostasis and obesity-related metabolic diseases, therefore addressing the therapeutic potential of novel and existing strategies (impact of nutrition/dietary modulation, and fecal microbiota transplantation) in the treatment of metabolic disease.https://www.mdpi.com/2079-7737/9/12/415microbiotaobesity-related metabolic diseasesdysbiosisprobiotics and prebioticsfecal microbiota transplantationclinical biochemistry and clinical molecular biology |
| spellingShingle | Andrea Ballini Salvatore Scacco Mariarosaria Boccellino Luigi Santacroce Roberto Arrigoni Microbiota and Obesity: Where Are We Now? Biology microbiota obesity-related metabolic diseases dysbiosis probiotics and prebiotics fecal microbiota transplantation clinical biochemistry and clinical molecular biology |
| title | Microbiota and Obesity: Where Are We Now? |
| title_full | Microbiota and Obesity: Where Are We Now? |
| title_fullStr | Microbiota and Obesity: Where Are We Now? |
| title_full_unstemmed | Microbiota and Obesity: Where Are We Now? |
| title_short | Microbiota and Obesity: Where Are We Now? |
| title_sort | microbiota and obesity where are we now |
| topic | microbiota obesity-related metabolic diseases dysbiosis probiotics and prebiotics fecal microbiota transplantation clinical biochemistry and clinical molecular biology |
| url | https://www.mdpi.com/2079-7737/9/12/415 |
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