Macrophage elastase (MMP-12): a pro-inflammatory mediator?
As many metalloproteinases (MMPs), macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes. Studies using animal models of acute and chronic pulmonary inflammatory diseases, such as pulmonary fibrosis and chronic...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2005-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900028 |
| _version_ | 1797704707343384576 |
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| author | Soazig Nénan Elisabeth Boichot Vincent Lagente Claude P Bertrand |
| author_facet | Soazig Nénan Elisabeth Boichot Vincent Lagente Claude P Bertrand |
| author_sort | Soazig Nénan |
| collection | DOAJ |
| description | As many metalloproteinases (MMPs), macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes. Studies using animal models of acute and chronic pulmonary inflammatory diseases, such as pulmonary fibrosis and chronic obstrutive pulmonary disease (COPD), have given evidences that MMP-12 is an important mediator of the pathogenesis of these diseases. However, as very few data regarding the direct involvement of MMP-12 in inflammatory process in the airways were available, we have instilled a recombinant form of human MMP-12 (rhMMP-12) in mouse airways. Hence, we have demonstrated that this instillation induced a severe inflammatory cell recruitment characterized by an early accumulation of neutrophils correlated with an increase in proinflammatory cytokines and in gelatinases and then by a relatively stable recruitment of macrophages in the lungs over a period of ten days. Another recent study suggests that resident alveolar macrophages and recruited neutrophils are not involved in the delayed macrophage recruitment. However, epithelial cells could be one of the main targets of rhMMP-12 in our model. We have also reported that a corticoid, dexamethasone, phosphodiesterase 4 inhibitor, rolipram and a non-selective MMP inhibitor, marimastat could reverse some of these inflammatory events. These data indicate that our rhMMP-12 model could mimic some of the inflammatory features observed in COPD patients and could be used for the pharmacological evaluation of new anti-inflammatory treatment. In this review, data demonstrating the involvement of MMP-12 in the pathogenesis of pulmonary fibrosis and COPD as well as our data showing a pro-inflammatory role for MMP-12 in mouse airways will be summarized. |
| first_indexed | 2024-03-12T05:25:25Z |
| format | Article |
| id | doaj.art-145e17e4524b4a278c27d1b4b150a91a |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:25:25Z |
| publishDate | 2005-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-145e17e4524b4a278c27d1b4b150a91a2023-09-03T07:24:44ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602005-03-0110016717210.1590/S0074-02762005000900028Macrophage elastase (MMP-12): a pro-inflammatory mediator?Soazig NénanElisabeth BoichotVincent LagenteClaude P BertrandAs many metalloproteinases (MMPs), macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes. Studies using animal models of acute and chronic pulmonary inflammatory diseases, such as pulmonary fibrosis and chronic obstrutive pulmonary disease (COPD), have given evidences that MMP-12 is an important mediator of the pathogenesis of these diseases. However, as very few data regarding the direct involvement of MMP-12 in inflammatory process in the airways were available, we have instilled a recombinant form of human MMP-12 (rhMMP-12) in mouse airways. Hence, we have demonstrated that this instillation induced a severe inflammatory cell recruitment characterized by an early accumulation of neutrophils correlated with an increase in proinflammatory cytokines and in gelatinases and then by a relatively stable recruitment of macrophages in the lungs over a period of ten days. Another recent study suggests that resident alveolar macrophages and recruited neutrophils are not involved in the delayed macrophage recruitment. However, epithelial cells could be one of the main targets of rhMMP-12 in our model. We have also reported that a corticoid, dexamethasone, phosphodiesterase 4 inhibitor, rolipram and a non-selective MMP inhibitor, marimastat could reverse some of these inflammatory events. These data indicate that our rhMMP-12 model could mimic some of the inflammatory features observed in COPD patients and could be used for the pharmacological evaluation of new anti-inflammatory treatment. In this review, data demonstrating the involvement of MMP-12 in the pathogenesis of pulmonary fibrosis and COPD as well as our data showing a pro-inflammatory role for MMP-12 in mouse airways will be summarized.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900028matrix metalloproteiansemetalloelastaseairway inflammationchronic obstructive pulmonary disease |
| spellingShingle | Soazig Nénan Elisabeth Boichot Vincent Lagente Claude P Bertrand Macrophage elastase (MMP-12): a pro-inflammatory mediator? Memorias do Instituto Oswaldo Cruz matrix metalloproteianse metalloelastase airway inflammation chronic obstructive pulmonary disease |
| title | Macrophage elastase (MMP-12): a pro-inflammatory mediator? |
| title_full | Macrophage elastase (MMP-12): a pro-inflammatory mediator? |
| title_fullStr | Macrophage elastase (MMP-12): a pro-inflammatory mediator? |
| title_full_unstemmed | Macrophage elastase (MMP-12): a pro-inflammatory mediator? |
| title_short | Macrophage elastase (MMP-12): a pro-inflammatory mediator? |
| title_sort | macrophage elastase mmp 12 a pro inflammatory mediator |
| topic | matrix metalloproteianse metalloelastase airway inflammation chronic obstructive pulmonary disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900028 |
| work_keys_str_mv | AT soazignenan macrophageelastasemmp12aproinflammatorymediator AT elisabethboichot macrophageelastasemmp12aproinflammatorymediator AT vincentlagente macrophageelastasemmp12aproinflammatorymediator AT claudepbertrand macrophageelastasemmp12aproinflammatorymediator |