Delay in onset of metabolic alkalosis during regional citrate anti-coagulation in continous renal replacement therapy with calcium-free replacement solution
Regional citrate anti-coagulation for continuous renal replacement therapy chelates calcium to produce the anti- coagulation effect. We hypothesise that a calcium-free replacement solution will require less citrate and produce fewer metabolic side effects. Fifty patients, in a Medical Inte...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Annals of Cardiac Anaesthesia |
| Subjects: | |
| Online Access: | http://www.annals.in/article.asp?issn=0971-9784;year=2009;volume=12;issue=2;spage=122;epage=126;aulast=See |
| _version_ | 1818561925391319040 |
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| author | See Kay Lee Margaret Mukhopadhyay Amartya |
| author_facet | See Kay Lee Margaret Mukhopadhyay Amartya |
| author_sort | See Kay |
| collection | DOAJ |
| description | Regional citrate anti-coagulation for continuous renal replacement therapy chelates calcium to produce the anti- coagulation effect. We hypothesise that a calcium-free replacement solution will require less citrate and produce fewer metabolic side effects. Fifty patients, in a Medical Intensive Care Unit of a tertiary teaching hospital (25 in each group), received continuous venovenous hemofiltration using either calcium-containing or calcium-free replacement solutions. Both groups had no significant differences in filter life, metabolic alkalosis, hypernatremia, hypocalcemia, and hypercalcemia. However, patients using calcium-containing solution developed metabolic alkalosis earlier, compared to patients using calcium-free solution (mean 24.6 hours,CI 0.8-48.4 vs. 37.2 hours, CI 9.4-65, <i> P </i> = 0.020). When calcium-containing replacement solution was used, more citrate was required (mean 280ml/h, CI 227.2-332.8 vs. 265ml/h, CI 203.4-326.6, <i> P </i> = 0.069), but less calcium was infused (mean 21.2 ml/h, CI 1.2-21.2 vs 51.6ml/h, CI 26.8-76.4, <i> P </i>≤ 0.0001). |
| first_indexed | 2024-12-14T00:57:04Z |
| format | Article |
| id | doaj.art-145f0ab878354b13a48d19c1f10a1e4b |
| institution | Directory Open Access Journal |
| issn | 0971-9784 |
| language | English |
| last_indexed | 2024-12-14T00:57:04Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Cardiac Anaesthesia |
| spelling | doaj.art-145f0ab878354b13a48d19c1f10a1e4b2022-12-21T23:23:28ZengWolters Kluwer Medknow PublicationsAnnals of Cardiac Anaesthesia0971-97842009-01-01122122126Delay in onset of metabolic alkalosis during regional citrate anti-coagulation in continous renal replacement therapy with calcium-free replacement solutionSee KayLee MargaretMukhopadhyay AmartyaRegional citrate anti-coagulation for continuous renal replacement therapy chelates calcium to produce the anti- coagulation effect. We hypothesise that a calcium-free replacement solution will require less citrate and produce fewer metabolic side effects. Fifty patients, in a Medical Intensive Care Unit of a tertiary teaching hospital (25 in each group), received continuous venovenous hemofiltration using either calcium-containing or calcium-free replacement solutions. Both groups had no significant differences in filter life, metabolic alkalosis, hypernatremia, hypocalcemia, and hypercalcemia. However, patients using calcium-containing solution developed metabolic alkalosis earlier, compared to patients using calcium-free solution (mean 24.6 hours,CI 0.8-48.4 vs. 37.2 hours, CI 9.4-65, <i> P </i> = 0.020). When calcium-containing replacement solution was used, more citrate was required (mean 280ml/h, CI 227.2-332.8 vs. 265ml/h, CI 203.4-326.6, <i> P </i> = 0.069), but less calcium was infused (mean 21.2 ml/h, CI 1.2-21.2 vs 51.6ml/h, CI 26.8-76.4, <i> P </i>≤ 0.0001).http://www.annals.in/article.asp?issn=0971-9784;year=2009;volume=12;issue=2;spage=122;epage=126;aulast=SeeRegional citrate anti-coagulationcontinuous renal replacement therapymetabolic alkalosisreplacement solutionfilter life |
| spellingShingle | See Kay Lee Margaret Mukhopadhyay Amartya Delay in onset of metabolic alkalosis during regional citrate anti-coagulation in continous renal replacement therapy with calcium-free replacement solution Annals of Cardiac Anaesthesia Regional citrate anti-coagulation continuous renal replacement therapy metabolic alkalosis replacement solution filter life |
| title | Delay in onset of metabolic alkalosis during regional citrate anti-coagulation in continous renal replacement therapy with calcium-free replacement solution |
| title_full | Delay in onset of metabolic alkalosis during regional citrate anti-coagulation in continous renal replacement therapy with calcium-free replacement solution |
| title_fullStr | Delay in onset of metabolic alkalosis during regional citrate anti-coagulation in continous renal replacement therapy with calcium-free replacement solution |
| title_full_unstemmed | Delay in onset of metabolic alkalosis during regional citrate anti-coagulation in continous renal replacement therapy with calcium-free replacement solution |
| title_short | Delay in onset of metabolic alkalosis during regional citrate anti-coagulation in continous renal replacement therapy with calcium-free replacement solution |
| title_sort | delay in onset of metabolic alkalosis during regional citrate anti coagulation in continous renal replacement therapy with calcium free replacement solution |
| topic | Regional citrate anti-coagulation continuous renal replacement therapy metabolic alkalosis replacement solution filter life |
| url | http://www.annals.in/article.asp?issn=0971-9784;year=2009;volume=12;issue=2;spage=122;epage=126;aulast=See |
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