Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia
Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-05-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/40580 |
| _version_ | 1811199497635627008 |
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| author | Carinna Hockham Supachai Ekwattanakit Samir Bhatt Bridget S Penman Sunetra Gupta Vip Viprakasit Frédéric B Piel |
| author_facet | Carinna Hockham Supachai Ekwattanakit Samir Bhatt Bridget S Penman Sunetra Gupta Vip Viprakasit Frédéric B Piel |
| author_sort | Carinna Hockham |
| collection | DOAJ |
| description | Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3595 (95% credible interval 1,717–6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia management. Our maps and newborn estimates are an important first step towards this aim.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter). |
| first_indexed | 2024-04-12T01:50:08Z |
| format | Article |
| id | doaj.art-145f9cf736854f4595b477c34180f22e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:50:08Z |
| publishDate | 2019-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-145f9cf736854f4595b477c34180f22e2022-12-22T03:52:58ZengeLife Sciences Publications LtdeLife2050-084X2019-05-01810.7554/eLife.40580Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast AsiaCarinna Hockham0https://orcid.org/0000-0003-2126-5350Supachai Ekwattanakit1Samir Bhatt2Bridget S Penman3Sunetra Gupta4https://orcid.org/0000-0002-9775-4006Vip Viprakasit5Frédéric B Piel6https://orcid.org/0000-0001-8131-7728The George Institute for Global Health, Sydney, Australia; Evolutionary Ecology of Infectious Disease Group, Department of Zoology, University of Oxford, Oxford, United KingdomThalassaemia Centre, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Infectious Disease Epidemiology, School of Public Health, Imperial College, London, United KingdomWarwick Infectious Disease Epidemiology Research, School of Life Sciences, Warwick University, Coventry, United KingdomEvolutionary Ecology of Infectious Disease Group, Department of Zoology, University of Oxford, Oxford, United KingdomThalassaemia Centre, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Paediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United KingdomSevere forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3595 (95% credible interval 1,717–6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia management. Our maps and newborn estimates are an important first step towards this aim.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).https://elifesciences.org/articles/40580Thalassaemiaspatial distributionnewborn prevalencegenetic diversity |
| spellingShingle | Carinna Hockham Supachai Ekwattanakit Samir Bhatt Bridget S Penman Sunetra Gupta Vip Viprakasit Frédéric B Piel Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia eLife Thalassaemia spatial distribution newborn prevalence genetic diversity |
| title | Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia |
| title_full | Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia |
| title_fullStr | Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia |
| title_full_unstemmed | Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia |
| title_short | Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia |
| title_sort | estimating the burden of α thalassaemia in thailand using a comprehensive prevalence database for southeast asia |
| topic | Thalassaemia spatial distribution newborn prevalence genetic diversity |
| url | https://elifesciences.org/articles/40580 |
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