Exercise and oxidative stress in hypoxia
There is considerable indirect proof that a hypobaric-hypoxic environment increases oxidative stress, which is usually reflected by an increase in hepatic TBARS levels and a decrease in Mn-SOD levels. In a hypobaric chamber experiment designed to simulate the summit of Mt. Fuji, we detected an incre...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Japanese Society of Physical Fitness and Sports Medicine
2013-11-01
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| Series: | Journal of Physical Fitness and Sports Medicine |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/2/4/2_481/_pdf/-char/en |
| _version_ | 1818833083522088960 |
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| author | Junichi Nagasawa Takako Kizaki Hideki Ohno |
| author_facet | Junichi Nagasawa Takako Kizaki Hideki Ohno |
| author_sort | Junichi Nagasawa |
| collection | DOAJ |
| description | There is considerable indirect proof that a hypobaric-hypoxic environment increases oxidative stress, which is usually reflected by an increase in hepatic TBARS levels and a decrease in Mn-SOD levels. In a hypobaric chamber experiment designed to simulate the summit of Mt. Fuji, we detected an increase in hydroperoxide, an oxidative stress marker, although the percentage increase was lower than that observed at Mt. Fuji. This highlights the compounding effects of environmental factors (ultraviolet rays, temperature differences, etc.) and indicates the importance of conducting measurements in the field. Although the production of oxygen radicals increases with accelerated aerobic metabolism, it has been reported that oxidative stress increases even in hypoxic environments. Activation of xanthine oxidase (XO), that accompanies ischemia-reperfusion (I/R) or an increase in white blood cells, etc. are considered as potential mechanisms by which oxidative stress increases in hypoxic environments. However, these mechanisms have not been fully clarified. |
| first_indexed | 2024-12-19T02:13:17Z |
| format | Article |
| id | doaj.art-1460ed09c02f4c88ad3e990fa94399a0 |
| institution | Directory Open Access Journal |
| issn | 2186-8131 2186-8123 |
| language | English |
| last_indexed | 2024-12-19T02:13:17Z |
| publishDate | 2013-11-01 |
| publisher | Japanese Society of Physical Fitness and Sports Medicine |
| record_format | Article |
| series | Journal of Physical Fitness and Sports Medicine |
| spelling | doaj.art-1460ed09c02f4c88ad3e990fa94399a02022-12-21T20:40:33ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232013-11-012448148610.7600/jpfsm.2.481jpfsmExercise and oxidative stress in hypoxiaJunichi Nagasawa0Takako Kizaki1Hideki Ohno2Bioscience and Technology Program, Department of Engineering Science, Graduate School of Informatics and Engineering, The University of Electro-CommunicationsDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of MedicineDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of MedicineThere is considerable indirect proof that a hypobaric-hypoxic environment increases oxidative stress, which is usually reflected by an increase in hepatic TBARS levels and a decrease in Mn-SOD levels. In a hypobaric chamber experiment designed to simulate the summit of Mt. Fuji, we detected an increase in hydroperoxide, an oxidative stress marker, although the percentage increase was lower than that observed at Mt. Fuji. This highlights the compounding effects of environmental factors (ultraviolet rays, temperature differences, etc.) and indicates the importance of conducting measurements in the field. Although the production of oxygen radicals increases with accelerated aerobic metabolism, it has been reported that oxidative stress increases even in hypoxic environments. Activation of xanthine oxidase (XO), that accompanies ischemia-reperfusion (I/R) or an increase in white blood cells, etc. are considered as potential mechanisms by which oxidative stress increases in hypoxic environments. However, these mechanisms have not been fully clarified.https://www.jstage.jst.go.jp/article/jpfsm/2/4/2_481/_pdf/-char/enoxidative stresshypoxiamountain climbingd-roms |
| spellingShingle | Junichi Nagasawa Takako Kizaki Hideki Ohno Exercise and oxidative stress in hypoxia Journal of Physical Fitness and Sports Medicine oxidative stress hypoxia mountain climbing d-roms |
| title | Exercise and oxidative stress in hypoxia |
| title_full | Exercise and oxidative stress in hypoxia |
| title_fullStr | Exercise and oxidative stress in hypoxia |
| title_full_unstemmed | Exercise and oxidative stress in hypoxia |
| title_short | Exercise and oxidative stress in hypoxia |
| title_sort | exercise and oxidative stress in hypoxia |
| topic | oxidative stress hypoxia mountain climbing d-roms |
| url | https://www.jstage.jst.go.jp/article/jpfsm/2/4/2_481/_pdf/-char/en |
| work_keys_str_mv | AT junichinagasawa exerciseandoxidativestressinhypoxia AT takakokizaki exerciseandoxidativestressinhypoxia AT hidekiohno exerciseandoxidativestressinhypoxia |