Decreased MiR-200a/141 Suppress Cell Migration and Proliferation by Targeting PTEN in Hirschsprung's Disease

Decreased MiR-200a/141 Suppress Cell Migration and Proliferation by Targeting PTEN in Hirschsprung's Disease

Background/Aims: Hirschsprung's disease (HSCR) is a genetic disorder of neural crest development. In this study, we investigated whether and how miR-200a and miR-141, belonging to miR-200 family, were involved in the pathogenesis of HSCR. Methods: Quantitative real time PCR and Western blot wer...

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Bibliographic Details
Main Authors: Hongxing Li, Junwei Tang, Hao Lei, Peng Cai, Hairong Zhu, Bo Li, Xiaoqun Xu, Yankai Xia, Weibing Tang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
HSCR
3'-UTR
Neural crest cell
Neural development
Pediatric
Online Access:http://www.karger.com/Article/FullText/363021

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