Antimicrobial Resistance Patterns of <i>Enterobacter cloacae</i> and <i>Klebsiella aerogenes</i> Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance Study
We retrospectively analyzed the antimicrobial data of <i>Enterobacter</i> spp. strains isolated from hospitalized subjects and outpatients over 20 years (2000–2019). A total of 2277 non-duplicate <i>Enterobacter</i> spp. isolates, 1037 from outpatients (45%) and 1240 from hos...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/4/775 |
| _version_ | 1827746158305345536 |
|---|---|
| author | Jari Intra Davide Carcione Roberta Maria Sala Claudia Siracusa Paolo Brambilla Valerio Leoni |
| author_facet | Jari Intra Davide Carcione Roberta Maria Sala Claudia Siracusa Paolo Brambilla Valerio Leoni |
| author_sort | Jari Intra |
| collection | DOAJ |
| description | We retrospectively analyzed the antimicrobial data of <i>Enterobacter</i> spp. strains isolated from hospitalized subjects and outpatients over 20 years (2000–2019). A total of 2277 non-duplicate <i>Enterobacter</i> spp. isolates, 1037 from outpatients (45%) and 1240 from hospitalized subjects (55%), were retrieved. Most of samples are infections of the urinary tract. Considering <i>Enterobacter aerogenes,</i> now classified as <i>Klebsiella aerogenes,</i> and <i>Enterobacter cloacae</i>, representing more than 90% of all isolates, except for aminoglycosides and fluroquinolones, which showed significant antibiotic decreasing trends (<i>p</i> < 0.01), none of the other antimicrobial agents tested showed significant changes in both groups (<i>p</i> > 0.05). Conversely, there was a significant increasing resistance trend for fosfomycin (<i>p</i> < 0.01), among both community and hospital-related subjects, most probably owing to uncontrolled and improper usage. Surveillance studies on antibiotic resistance at the local and regional level are required to detect new resistance mechanisms, reduce inappropriate antimicrobial consumption, and increase the focus on antimicrobial stewardship. |
| first_indexed | 2024-03-11T05:17:35Z |
| format | Article |
| id | doaj.art-1460ff9e98d34995b5c964a444c4f162 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T05:17:35Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1460ff9e98d34995b5c964a444c4f1622023-11-17T18:03:52ZengMDPI AGAntibiotics2079-63822023-04-0112477510.3390/antibiotics12040775Antimicrobial Resistance Patterns of <i>Enterobacter cloacae</i> and <i>Klebsiella aerogenes</i> Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance StudyJari Intra0Davide Carcione1Roberta Maria Sala2Claudia Siracusa3Paolo Brambilla4Valerio Leoni5Clinical Chemistry Laboratory, Fondazione IRCCS San Gerardo Dei Tintori, via Pergolesi 33, 20900 Monza, MB, ItalyLaboratory of Medicine and Microbiology, Busto Arsizio Hospital—ASST Valle Olona, via Arnaldo da Brescia, 1, 21052 Busto Arsizio, VA, ItalyDepartment of Laboratory Medicine, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale della Brianza, ASST-Brianza, Desio Hospital, via Mazzini 1, 20833 Desio, MB, ItalyDepartment of Laboratory Medicine, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale della Brianza, ASST-Brianza, Desio Hospital, via Mazzini 1, 20833 Desio, MB, ItalyDepartment of Laboratory Medicine, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale della Brianza, ASST-Brianza, Desio Hospital, via Mazzini 1, 20833 Desio, MB, ItalyDepartment of Laboratory Medicine, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale della Brianza, ASST-Brianza, Desio Hospital, via Mazzini 1, 20833 Desio, MB, ItalyWe retrospectively analyzed the antimicrobial data of <i>Enterobacter</i> spp. strains isolated from hospitalized subjects and outpatients over 20 years (2000–2019). A total of 2277 non-duplicate <i>Enterobacter</i> spp. isolates, 1037 from outpatients (45%) and 1240 from hospitalized subjects (55%), were retrieved. Most of samples are infections of the urinary tract. Considering <i>Enterobacter aerogenes,</i> now classified as <i>Klebsiella aerogenes,</i> and <i>Enterobacter cloacae</i>, representing more than 90% of all isolates, except for aminoglycosides and fluroquinolones, which showed significant antibiotic decreasing trends (<i>p</i> < 0.01), none of the other antimicrobial agents tested showed significant changes in both groups (<i>p</i> > 0.05). Conversely, there was a significant increasing resistance trend for fosfomycin (<i>p</i> < 0.01), among both community and hospital-related subjects, most probably owing to uncontrolled and improper usage. Surveillance studies on antibiotic resistance at the local and regional level are required to detect new resistance mechanisms, reduce inappropriate antimicrobial consumption, and increase the focus on antimicrobial stewardship.https://www.mdpi.com/2079-6382/12/4/775antibiotic resistance<i>Enterobacter cloacae</i><i>Klebsiella aerogenes</i>epidemiologyfosfomycinsurveillance study |
| spellingShingle | Jari Intra Davide Carcione Roberta Maria Sala Claudia Siracusa Paolo Brambilla Valerio Leoni Antimicrobial Resistance Patterns of <i>Enterobacter cloacae</i> and <i>Klebsiella aerogenes</i> Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance Study Antibiotics antibiotic resistance <i>Enterobacter cloacae</i> <i>Klebsiella aerogenes</i> epidemiology fosfomycin surveillance study |
| title | Antimicrobial Resistance Patterns of <i>Enterobacter cloacae</i> and <i>Klebsiella aerogenes</i> Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance Study |
| title_full | Antimicrobial Resistance Patterns of <i>Enterobacter cloacae</i> and <i>Klebsiella aerogenes</i> Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance Study |
| title_fullStr | Antimicrobial Resistance Patterns of <i>Enterobacter cloacae</i> and <i>Klebsiella aerogenes</i> Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance Study |
| title_full_unstemmed | Antimicrobial Resistance Patterns of <i>Enterobacter cloacae</i> and <i>Klebsiella aerogenes</i> Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance Study |
| title_short | Antimicrobial Resistance Patterns of <i>Enterobacter cloacae</i> and <i>Klebsiella aerogenes</i> Strains Isolated from Clinical Specimens: A Twenty-Year Surveillance Study |
| title_sort | antimicrobial resistance patterns of i enterobacter cloacae i and i klebsiella aerogenes i strains isolated from clinical specimens a twenty year surveillance study |
| topic | antibiotic resistance <i>Enterobacter cloacae</i> <i>Klebsiella aerogenes</i> epidemiology fosfomycin surveillance study |
| url | https://www.mdpi.com/2079-6382/12/4/775 |
| work_keys_str_mv | AT jariintra antimicrobialresistancepatternsofienterobactercloacaeiandiklebsiellaaerogenesistrainsisolatedfromclinicalspecimensatwentyyearsurveillancestudy AT davidecarcione antimicrobialresistancepatternsofienterobactercloacaeiandiklebsiellaaerogenesistrainsisolatedfromclinicalspecimensatwentyyearsurveillancestudy AT robertamariasala antimicrobialresistancepatternsofienterobactercloacaeiandiklebsiellaaerogenesistrainsisolatedfromclinicalspecimensatwentyyearsurveillancestudy AT claudiasiracusa antimicrobialresistancepatternsofienterobactercloacaeiandiklebsiellaaerogenesistrainsisolatedfromclinicalspecimensatwentyyearsurveillancestudy AT paolobrambilla antimicrobialresistancepatternsofienterobactercloacaeiandiklebsiellaaerogenesistrainsisolatedfromclinicalspecimensatwentyyearsurveillancestudy AT valerioleoni antimicrobialresistancepatternsofienterobactercloacaeiandiklebsiellaaerogenesistrainsisolatedfromclinicalspecimensatwentyyearsurveillancestudy |