Evaluation of the Effects of Chia (<i>Salvia hispanica</i> L.) Leaves Ethanolic Extracts Supplementation on Biochemical and Hepatic Markers on Diet-Induced Obese Mice
Obesity is a significant health concern affecting 13% of the world’s population. It is often associated with insulin resistance and metabolic-associated fatty liver disease (MAFLD), which can cause chronic inflammation in the liver and adipose tissue. Obese hepatocytes show increased lipid droplets...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/5/1108 |
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| author | Gabriela Maturana Javiera Segovia Claudio Olea-Azar Ernesto Uribe-Oporto Alejandra Espinosa María Carolina Zúñiga-López |
| author_facet | Gabriela Maturana Javiera Segovia Claudio Olea-Azar Ernesto Uribe-Oporto Alejandra Espinosa María Carolina Zúñiga-López |
| author_sort | Gabriela Maturana |
| collection | DOAJ |
| description | Obesity is a significant health concern affecting 13% of the world’s population. It is often associated with insulin resistance and metabolic-associated fatty liver disease (MAFLD), which can cause chronic inflammation in the liver and adipose tissue. Obese hepatocytes show increased lipid droplets and lipid peroxidation, which can lead to the progression of liver damage. Polyphenols have been shown to have the ability to reduce lipid peroxidation, thereby promoting hepatocyte health. Chia leaves, a by-product of chia seed production, are a natural source of bioactive antioxidant compounds, such as cinnamic acids and flavonoids, which have antioxidant and anti-inflammatory properties. In this study, chia leaves’ ethanolic extracts of two seed phenotypes were tested on diet-induced obese mice to evaluate their therapeutic potential. Results show that the chia leaf extract positively affected insulin resistance and lipid peroxidation in the liver. In addition, the extract improved the HOMA-IR index compared to the obese control group, reducing the number and size of lipid droplets and lipid peroxidation. These results suggest that chia leaf extract may help treat insulin resistance and liver damage associated with MAFLD. |
| first_indexed | 2024-03-11T03:59:18Z |
| format | Article |
| id | doaj.art-1463436dedb1495491fa867b44882f49 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T03:59:18Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1463436dedb1495491fa867b44882f492023-11-18T00:15:43ZengMDPI AGAntioxidants2076-39212023-05-01125110810.3390/antiox12051108Evaluation of the Effects of Chia (<i>Salvia hispanica</i> L.) Leaves Ethanolic Extracts Supplementation on Biochemical and Hepatic Markers on Diet-Induced Obese MiceGabriela Maturana0Javiera Segovia1Claudio Olea-Azar2Ernesto Uribe-Oporto3Alejandra Espinosa4María Carolina Zúñiga-López5Department of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, ChileDepartment of Medical Technology, University of Chile, Santiago 8380453, ChileDepartment of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, ChileDepartment of Medical Technology, University of Chile, Santiago 8380453, ChileDepartment of Medical Technology, University of Chile, Santiago 8380453, ChileDepartment of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, ChileObesity is a significant health concern affecting 13% of the world’s population. It is often associated with insulin resistance and metabolic-associated fatty liver disease (MAFLD), which can cause chronic inflammation in the liver and adipose tissue. Obese hepatocytes show increased lipid droplets and lipid peroxidation, which can lead to the progression of liver damage. Polyphenols have been shown to have the ability to reduce lipid peroxidation, thereby promoting hepatocyte health. Chia leaves, a by-product of chia seed production, are a natural source of bioactive antioxidant compounds, such as cinnamic acids and flavonoids, which have antioxidant and anti-inflammatory properties. In this study, chia leaves’ ethanolic extracts of two seed phenotypes were tested on diet-induced obese mice to evaluate their therapeutic potential. Results show that the chia leaf extract positively affected insulin resistance and lipid peroxidation in the liver. In addition, the extract improved the HOMA-IR index compared to the obese control group, reducing the number and size of lipid droplets and lipid peroxidation. These results suggest that chia leaf extract may help treat insulin resistance and liver damage associated with MAFLD.https://www.mdpi.com/2076-3921/12/5/1108<i>Salvia hispanica</i> L.leaf extractshepatic damageobesity |
| spellingShingle | Gabriela Maturana Javiera Segovia Claudio Olea-Azar Ernesto Uribe-Oporto Alejandra Espinosa María Carolina Zúñiga-López Evaluation of the Effects of Chia (<i>Salvia hispanica</i> L.) Leaves Ethanolic Extracts Supplementation on Biochemical and Hepatic Markers on Diet-Induced Obese Mice Antioxidants <i>Salvia hispanica</i> L. leaf extracts hepatic damage obesity |
| title | Evaluation of the Effects of Chia (<i>Salvia hispanica</i> L.) Leaves Ethanolic Extracts Supplementation on Biochemical and Hepatic Markers on Diet-Induced Obese Mice |
| title_full | Evaluation of the Effects of Chia (<i>Salvia hispanica</i> L.) Leaves Ethanolic Extracts Supplementation on Biochemical and Hepatic Markers on Diet-Induced Obese Mice |
| title_fullStr | Evaluation of the Effects of Chia (<i>Salvia hispanica</i> L.) Leaves Ethanolic Extracts Supplementation on Biochemical and Hepatic Markers on Diet-Induced Obese Mice |
| title_full_unstemmed | Evaluation of the Effects of Chia (<i>Salvia hispanica</i> L.) Leaves Ethanolic Extracts Supplementation on Biochemical and Hepatic Markers on Diet-Induced Obese Mice |
| title_short | Evaluation of the Effects of Chia (<i>Salvia hispanica</i> L.) Leaves Ethanolic Extracts Supplementation on Biochemical and Hepatic Markers on Diet-Induced Obese Mice |
| title_sort | evaluation of the effects of chia i salvia hispanica i l leaves ethanolic extracts supplementation on biochemical and hepatic markers on diet induced obese mice |
| topic | <i>Salvia hispanica</i> L. leaf extracts hepatic damage obesity |
| url | https://www.mdpi.com/2076-3921/12/5/1108 |
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