The Early Efficacy of Topical Levocabastine in Patients with Allergic Conjunctivitis
Background: We investigated the early efficacy of topical levocabastine, an H1 histamine-receptor antagonist, in improving the clinical symptoms of allergic conjunctivitis. Methods: Thirty-six patients with allergic conjunctivitis were enrolled. One drop of levocabastine was instilled in one eye and...
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| Format: | Article |
| Language: | English |
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Elsevier
2006-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015309801 |
| _version_ | 1818586273959378944 |
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| author | Hiroshi Fujishima Kazumi Fukagawa Yoji Takano Shigeki Okamoto Yayoi Nakagawa Eiichi Uchio Norihiko Yokoi Atsuki Fukushima Etsuko Takamura |
| author_facet | Hiroshi Fujishima Kazumi Fukagawa Yoji Takano Shigeki Okamoto Yayoi Nakagawa Eiichi Uchio Norihiko Yokoi Atsuki Fukushima Etsuko Takamura |
| author_sort | Hiroshi Fujishima |
| collection | DOAJ |
| description | Background: We investigated the early efficacy of topical levocabastine, an H1 histamine-receptor antagonist, in improving the clinical symptoms of allergic conjunctivitis.
Methods: Thirty-six patients with allergic conjunctivitis were enrolled. One drop of levocabastine was instilled in one eye and one drop of artificial tears in the contralateral eye. Clinical examinations were performed before, and 15 and 30 minutes after instillation. Symptoms of itching and signs of injection were assessed at each time point.
Results: Both levocabastine and artificial tears resulted in a statistically significant reduction in ocular itching. However, levocabastine was significantly more effective.
Conclusions: Although artificial tears had a positive effect in reducing symptoms of allergic conjunctivitis, by the washing out of allergens, levocabastine was more effective than artificial tears in controlling acute symptoms of allergic conjunctivitis, demonstrating that the selective H1 histamine-receptor antagonist action of levocabastine is rapidly effective in a clinical setting. |
| first_indexed | 2024-12-16T08:50:21Z |
| format | Article |
| id | doaj.art-146384b969ff46ce8caebd4da971ae0e |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-16T08:50:21Z |
| publishDate | 2006-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-146384b969ff46ce8caebd4da971ae0e2022-12-21T22:37:28ZengElsevierAllergology International1323-89302006-01-0155330130310.2332/allergolint.55.301The Early Efficacy of Topical Levocabastine in Patients with Allergic ConjunctivitisHiroshi Fujishima0Kazumi Fukagawa1Yoji Takano2Shigeki Okamoto3Yayoi Nakagawa4Eiichi Uchio5Norihiko Yokoi6Atsuki Fukushima7Etsuko Takamura8Department of Ophthalmology, Keio University School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.Department of Ophthalmology, Keio University School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.Department of Ophthalmology, Keio University School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.Kozuka Eye Clinic, Ehime, Japan.Nakagawa Eye Clinic, Osaka, Japan.Department of Ophthalmology, Yokohama City University Medical Center, Kanagawa, Japan.Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.Department of Ophthalmology, Kochi Medical School, Kochi, Japan.Department of Ophthalmology, Tokyo Women's Medical University, Tokyo, Japan.Background: We investigated the early efficacy of topical levocabastine, an H1 histamine-receptor antagonist, in improving the clinical symptoms of allergic conjunctivitis. Methods: Thirty-six patients with allergic conjunctivitis were enrolled. One drop of levocabastine was instilled in one eye and one drop of artificial tears in the contralateral eye. Clinical examinations were performed before, and 15 and 30 minutes after instillation. Symptoms of itching and signs of injection were assessed at each time point. Results: Both levocabastine and artificial tears resulted in a statistically significant reduction in ocular itching. However, levocabastine was significantly more effective. Conclusions: Although artificial tears had a positive effect in reducing symptoms of allergic conjunctivitis, by the washing out of allergens, levocabastine was more effective than artificial tears in controlling acute symptoms of allergic conjunctivitis, demonstrating that the selective H1 histamine-receptor antagonist action of levocabastine is rapidly effective in a clinical setting.http://www.sciencedirect.com/science/article/pii/S1323893015309801allergic conjunctivitisartificial tearsH1 antagonisthistaminelevocabastine |
| spellingShingle | Hiroshi Fujishima Kazumi Fukagawa Yoji Takano Shigeki Okamoto Yayoi Nakagawa Eiichi Uchio Norihiko Yokoi Atsuki Fukushima Etsuko Takamura The Early Efficacy of Topical Levocabastine in Patients with Allergic Conjunctivitis Allergology International allergic conjunctivitis artificial tears H1 antagonist histamine levocabastine |
| title | The Early Efficacy of Topical Levocabastine in Patients with Allergic Conjunctivitis |
| title_full | The Early Efficacy of Topical Levocabastine in Patients with Allergic Conjunctivitis |
| title_fullStr | The Early Efficacy of Topical Levocabastine in Patients with Allergic Conjunctivitis |
| title_full_unstemmed | The Early Efficacy of Topical Levocabastine in Patients with Allergic Conjunctivitis |
| title_short | The Early Efficacy of Topical Levocabastine in Patients with Allergic Conjunctivitis |
| title_sort | early efficacy of topical levocabastine in patients with allergic conjunctivitis |
| topic | allergic conjunctivitis artificial tears H1 antagonist histamine levocabastine |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015309801 |
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