In-Frame Variants in STAG3 Gene Cause Premature Ovarian Insufficiency

In-Frame Variants in STAG3 Gene Cause Premature Ovarian Insufficiency

Premature ovarian insufficiency (POI) is a severe clinical syndrome defined by ovarian dysfunction in women less than 40 years old who generally manifest with infertility, menstrual disturbance, elevated gonadotrophins, and low estradiol levels. STAG3 is considered a genetic aetiology of POI, which...

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Bibliographic Details
Main Authors: Wen-Juan Xiao, Wen-Bin He, Ya-Xin Zhang, Lan-Lan Meng, Guang-Xiu Lu, Ge Lin, Yue-Qiu Tan, Juan Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
premature ovarian insufficiency
STAG3 gene
in-frame variant
fluorescence localization
co-immunoprecipitation
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01016/full

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