SUCCESSFUL TREATMENT OF INOPERABLE THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT WITH SILDENAFIL IN HIGH DOSES
The currentguidelines on chronic thromboembolic pulmonary hypertension (CTEPH) treatment consider pulmonary thrombendarterectomy as the first therapy choice. In case of inoperability due to severe patient's condition, distal lesions of pulmonary vessels, extremely high pulmonary vascular resist...
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| Format: | Article |
| Language: | Russian |
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InterMedservice
2014-12-01
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| Series: | Евразийский Кардиологический Журнал |
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| Online Access: | https://www.heartj.asia/jour/article/view/5614 |
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| author | Z. H. Dadacheva T. V. Martynyuk M. A. Saidova N. M. Danilov K. V. Mershin I. Ye. Chazova |
| author_facet | Z. H. Dadacheva T. V. Martynyuk M. A. Saidova N. M. Danilov K. V. Mershin I. Ye. Chazova |
| author_sort | Z. H. Dadacheva |
| collection | DOAJ |
| description | The currentguidelines on chronic thromboembolic pulmonary hypertension (CTEPH) treatment consider pulmonary thrombendarterectomy as the first therapy choice. In case of inoperability due to severe patient's condition, distal lesions of pulmonary vessels, extremely high pulmonary vascular resistance, medical treatment for CTEPH includes life-long anticoagulation therapy and reduction of heart failure symptoms. This clinical case of the 59-y-old patient M. with inoperable CTEPH demonstrates the efficacy of phosphodiеsterase-5 inhibitor Sildenafil usedin high doses. The diagnosis was confirmed by the results of the complete diagnostic process including right heart catheterization and pulmonary angiography. The initial functional class was assessed as III in accordance with WHO classification. Sildenafil 60 mg daily was added tothe standard therapy (anticoagulant, calcium channel blocker) for initial four weeks. To the 4wk visit Sildenafil dose was increased to 240 mgdailytaking into account good tolerance of the treatment.The significant improvement of functional class, positive dynamic ofhemodynamic and echo parameters were found to 4 month of follow-up. |
| first_indexed | 2024-04-10T02:45:15Z |
| format | Article |
| id | doaj.art-1467e5ecd18845fe8742f80ce37168f9 |
| institution | Directory Open Access Journal |
| issn | 2225-1685 2305-0748 |
| language | Russian |
| last_indexed | 2024-04-10T02:45:15Z |
| publishDate | 2014-12-01 |
| publisher | InterMedservice |
| record_format | Article |
| series | Евразийский Кардиологический Журнал |
| spelling | doaj.art-1467e5ecd18845fe8742f80ce37168f92023-03-13T07:47:27ZrusInterMedserviceЕвразийский Кардиологический Журнал2225-16852305-07482014-12-0104344210.38109/2225-1685-2014-4-34-425611SUCCESSFUL TREATMENT OF INOPERABLE THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT WITH SILDENAFIL IN HIGH DOSESZ. H. Dadacheva0T. V. Martynyuk1M. A. Saidova2N. M. Danilov3K. V. Mershin4I. Ye. Chazova5ФГБУ «Российский кардиологический научно-производственный комплекс» МЗ РФФГБУ «Российский кардиологический научно-производственный комплекс» МЗ РФФГБУ «Российский кардиологический научно-производственный комплекс» МЗ РФФГБУ «Российский кардиологический научно-производственный комплекс» МЗ РФФГБУ «Российский кардиологический научно-производственный комплекс» МЗ РФФГБУ «Российский кардиологический научно-производственный комплекс» МЗ РФThe currentguidelines on chronic thromboembolic pulmonary hypertension (CTEPH) treatment consider pulmonary thrombendarterectomy as the first therapy choice. In case of inoperability due to severe patient's condition, distal lesions of pulmonary vessels, extremely high pulmonary vascular resistance, medical treatment for CTEPH includes life-long anticoagulation therapy and reduction of heart failure symptoms. This clinical case of the 59-y-old patient M. with inoperable CTEPH demonstrates the efficacy of phosphodiеsterase-5 inhibitor Sildenafil usedin high doses. The diagnosis was confirmed by the results of the complete diagnostic process including right heart catheterization and pulmonary angiography. The initial functional class was assessed as III in accordance with WHO classification. Sildenafil 60 mg daily was added tothe standard therapy (anticoagulant, calcium channel blocker) for initial four weeks. To the 4wk visit Sildenafil dose was increased to 240 mgdailytaking into account good tolerance of the treatment.The significant improvement of functional class, positive dynamic ofhemodynamic and echo parameters were found to 4 month of follow-up.https://www.heartj.asia/jour/article/view/5614легочная гипертензияхроническая тромбоэмболическая лёгочная гипертензияингибитор фосфодиэстеразы типа 5силденафилpulmonary hypertensionchronic thromboembolic pulmonary hypertensionphosphodiesterase type 5 inhibitorsildenafil |
| spellingShingle | Z. H. Dadacheva T. V. Martynyuk M. A. Saidova N. M. Danilov K. V. Mershin I. Ye. Chazova SUCCESSFUL TREATMENT OF INOPERABLE THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT WITH SILDENAFIL IN HIGH DOSES Евразийский Кардиологический Журнал легочная гипертензия хроническая тромбоэмболическая лёгочная гипертензия ингибитор фосфодиэстеразы типа 5 силденафил pulmonary hypertension chronic thromboembolic pulmonary hypertension phosphodiesterase type 5 inhibitor sildenafil |
| title | SUCCESSFUL TREATMENT OF INOPERABLE THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT WITH SILDENAFIL IN HIGH DOSES |
| title_full | SUCCESSFUL TREATMENT OF INOPERABLE THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT WITH SILDENAFIL IN HIGH DOSES |
| title_fullStr | SUCCESSFUL TREATMENT OF INOPERABLE THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT WITH SILDENAFIL IN HIGH DOSES |
| title_full_unstemmed | SUCCESSFUL TREATMENT OF INOPERABLE THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT WITH SILDENAFIL IN HIGH DOSES |
| title_short | SUCCESSFUL TREATMENT OF INOPERABLE THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT WITH SILDENAFIL IN HIGH DOSES |
| title_sort | successful treatment of inoperable thromboembolic pulmonary hypertension patient with sildenafil in high doses |
| topic | легочная гипертензия хроническая тромбоэмболическая лёгочная гипертензия ингибитор фосфодиэстеразы типа 5 силденафил pulmonary hypertension chronic thromboembolic pulmonary hypertension phosphodiesterase type 5 inhibitor sildenafil |
| url | https://www.heartj.asia/jour/article/view/5614 |
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