Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs
Good biological properties for titanium implants will shorten the treatment cycle and improve patient comfort, which are also the main goals of dentistry and orthopaedics. At present, the biological properties of titanium implants are mainly enhanced in two aspects: their surface chemistry and surfa...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1699829 |
| _version_ | 1827181442882338816 |
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| author | Wuchao Zhou Tiesheng Wang Yanzi Gan Jian Yang Hongshui Zhu Anxun Wang Yujiang Wang Weihong Xi |
| author_facet | Wuchao Zhou Tiesheng Wang Yanzi Gan Jian Yang Hongshui Zhu Anxun Wang Yujiang Wang Weihong Xi |
| author_sort | Wuchao Zhou |
| collection | DOAJ |
| description | Good biological properties for titanium implants will shorten the treatment cycle and improve patient comfort, which are also the main goals of dentistry and orthopaedics. At present, the biological properties of titanium implants are mainly enhanced in two aspects: their surface chemistry and surface morphology. In this study, a surface modification strategy combining bioactive trace elements with surface micromorphology modification was used to enhance the biological properties of pure titanium. A new coating incorporating silicon micropore/microsphere topography was prepared on a titanium plate by micro-arc oxidation (MAO) technology. The properties of the coating and its effects on the adhesion and osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) were further analyzed. The experimental results show that a coating doped with amorphous silicon with micropore/microsphere topography was incorporated onto the titanium surface and the surface roughness in the treated groups was obviously higher than that in the Ti group. In vitro, the presence of a silicon-incorporating coating with a micropore/microsphere topography on the titanium surface significantly enhanced the initial adhesion, proliferation and osteogenic differentiation of BMSCs. These results indicate that the silicon-incorporating coating with micropore/microsphere topography has potential applications in dentistry and orthopaedics. |
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| issn | 2169-1401 2169-141X |
| language | English |
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| spelling | doaj.art-1469e659d70c40929f98d570bd3448d92024-07-23T18:44:29ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-0148123024110.1080/21691401.2019.1699829Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCsWuchao Zhou0Tiesheng Wang1Yanzi Gan2Jian Yang3Hongshui Zhu4Anxun Wang5Yujiang Wang6Weihong Xi7Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Medical College of Nanchang University, Nanchang, ChinaDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Medical College of Nanchang University, Nanchang, ChinaDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Medical College of Nanchang University, Nanchang, ChinaDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Medical College of Nanchang University, Nanchang, ChinaDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Medical College of Nanchang University, Nanchang, ChinaDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Medical College of Nanchang University, Nanchang, ChinaDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Medical College of Nanchang University, Nanchang, ChinaGood biological properties for titanium implants will shorten the treatment cycle and improve patient comfort, which are also the main goals of dentistry and orthopaedics. At present, the biological properties of titanium implants are mainly enhanced in two aspects: their surface chemistry and surface morphology. In this study, a surface modification strategy combining bioactive trace elements with surface micromorphology modification was used to enhance the biological properties of pure titanium. A new coating incorporating silicon micropore/microsphere topography was prepared on a titanium plate by micro-arc oxidation (MAO) technology. The properties of the coating and its effects on the adhesion and osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) were further analyzed. The experimental results show that a coating doped with amorphous silicon with micropore/microsphere topography was incorporated onto the titanium surface and the surface roughness in the treated groups was obviously higher than that in the Ti group. In vitro, the presence of a silicon-incorporating coating with a micropore/microsphere topography on the titanium surface significantly enhanced the initial adhesion, proliferation and osteogenic differentiation of BMSCs. These results indicate that the silicon-incorporating coating with micropore/microsphere topography has potential applications in dentistry and orthopaedics.https://www.tandfonline.com/doi/10.1080/21691401.2019.1699829Titaniummicro-arc oxidationsiliconBMSCsosteogenic differentiation |
| spellingShingle | Wuchao Zhou Tiesheng Wang Yanzi Gan Jian Yang Hongshui Zhu Anxun Wang Yujiang Wang Weihong Xi Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs Artificial Cells, Nanomedicine, and Biotechnology Titanium micro-arc oxidation silicon BMSCs osteogenic differentiation |
| title | Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs |
| title_full | Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs |
| title_fullStr | Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs |
| title_full_unstemmed | Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs |
| title_short | Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs |
| title_sort | effect of micropore microsphere topography and a silicon incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of bmscs |
| topic | Titanium micro-arc oxidation silicon BMSCs osteogenic differentiation |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1699829 |
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