Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches
Abstract Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
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BMC
2023-10-01
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Series: | Molecular Cancer |
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Online Access: | https://doi.org/10.1186/s12943-023-01854-3 |
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author | Nazeer Hasan Arif Nadaf Mohammad Imran Umme Jiba Afsana Sheikh Waleed H. Almalki Salem Salman Almujri Yousuf Hussain Mohammed Prashant Kesharwani Farhan Jalees Ahmad |
author_facet | Nazeer Hasan Arif Nadaf Mohammad Imran Umme Jiba Afsana Sheikh Waleed H. Almalki Salem Salman Almujri Yousuf Hussain Mohammed Prashant Kesharwani Farhan Jalees Ahmad |
author_sort | Nazeer Hasan |
collection | DOAJ |
description | Abstract Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination therapy, molecular targets associated with cancer growth and metastasis, and special emphasis on nanotechnology-based approaches for downregulating the deleterious disease. A detailed analysis with respect to types of nanoparticles and their scope in overcoming multidrug resistance as well as associated clinical trials has been discussed. Graphical Abstract |
first_indexed | 2024-03-10T22:12:02Z |
format | Article |
id | doaj.art-146d35b96a26428a937477ab3dd1ec2d |
institution | Directory Open Access Journal |
issn | 1476-4598 |
language | English |
last_indexed | 2024-03-10T22:12:02Z |
publishDate | 2023-10-01 |
publisher | BMC |
record_format | Article |
series | Molecular Cancer |
spelling | doaj.art-146d35b96a26428a937477ab3dd1ec2d2023-11-19T12:34:28ZengBMCMolecular Cancer1476-45982023-10-0122117010.1186/s12943-023-01854-3Skin cancer: understanding the journey of transformation from conventional to advanced treatment approachesNazeer Hasan0Arif Nadaf1Mohammad Imran2Umme Jiba3Afsana Sheikh4Waleed H. Almalki5Salem Salman Almujri6Yousuf Hussain Mohammed7Prashant Kesharwani8Farhan Jalees Ahmad9Department of Pharmaceutics, School of Pharmaceutical Education and ResearchDepartment of Pharmaceutics, School of Pharmaceutical Education and ResearchFrazer Institute, Faculty of Medicine, University of QueenslandDepartment of Pharmaceutics, School of Pharmaceutical Education and ResearchDepartment of Pharmaceutics, School of Pharmaceutical Education and ResearchDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura UniversityDepartment of Pharmacology, College of Pharmacy, King Khalid UniversityFrazer Institute, Faculty of Medicine, University of QueenslandDepartment of Pharmaceutics, School of Pharmaceutical Education and ResearchDepartment of Pharmaceutics, School of Pharmaceutical Education and ResearchAbstract Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination therapy, molecular targets associated with cancer growth and metastasis, and special emphasis on nanotechnology-based approaches for downregulating the deleterious disease. A detailed analysis with respect to types of nanoparticles and their scope in overcoming multidrug resistance as well as associated clinical trials has been discussed. Graphical Abstracthttps://doi.org/10.1186/s12943-023-01854-3Skin cancerMelanomaNon-melanomaEtiologyPhytocompoundsToxicity |
spellingShingle | Nazeer Hasan Arif Nadaf Mohammad Imran Umme Jiba Afsana Sheikh Waleed H. Almalki Salem Salman Almujri Yousuf Hussain Mohammed Prashant Kesharwani Farhan Jalees Ahmad Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches Molecular Cancer Skin cancer Melanoma Non-melanoma Etiology Phytocompounds Toxicity |
title | Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches |
title_full | Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches |
title_fullStr | Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches |
title_full_unstemmed | Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches |
title_short | Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches |
title_sort | skin cancer understanding the journey of transformation from conventional to advanced treatment approaches |
topic | Skin cancer Melanoma Non-melanoma Etiology Phytocompounds Toxicity |
url | https://doi.org/10.1186/s12943-023-01854-3 |
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