Modeling CaMKII-mediated regulation of L-type Ca2+ channels and ryanodine receptors in the heart

Modeling CaMKII-mediated regulation of L-type Ca2+ channels and ryanodine receptors in the heart

Excitation-contraction coupling (ECC) in the cardiac myocyte is mediated by a number of highly integrated mechanisms of intracellular Ca2+ transport. Voltage- and Ca2+-dependent L-type Ca2+ channels (LCCs) allow for Ca2+ entry into the myocyte, which then binds to nearby ryanodine receptors (RyRs) a...

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Bibliographic Details
Main Authors: Joseph L Greenstein, Panagiota T Foteinou, Yasmin L Hashambhoy-Ramsay, Raimond L Winslow
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Pharmacology
Subjects:
CaMKII
computational modeling
cardiac myocyte
cell signalling
excitation-contraction coupling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00060/full

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