Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer

Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer

Abstract Ferroptosis is a type of regulated cell death characterized by iron accumulation and lipid peroxidation. The molecular mechanisms underlying ferroptosis regulation in non-small cell lung cancer (NSCLC) are poorly understood. In this study, we found that protein kinase A (PKA) inhibition enh...

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Bibliographic Details
Main Authors: Guangyao Shan, Guoshu Bi, Guangyin Zhao, Jiaqi Liang, Yunyi Bian, Huan Zhang, Xing Jin, Zhengyang Hu, Guangyu Yao, Hong Fan, Cheng Zhan
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Respiratory Research
Subjects:
Ferroptosis
Lipid metabolism
Transcription factor
Non-small cell lung cancer
Online Access:https://doi.org/10.1186/s12931-023-02567-3

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