Mortality of tuberculosis patients in Chennai, India
OBJECTIVE: We aimed to measure the mortality rate and excess general mortality as well as identify groups at high risk for mortality among a cohort of tuberculosis patients treated in Chennai Corporation clinics in south India. METHODS: In this retrospective cohort study we followed up 2674 patients...
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| Format: | Article |
| Language: | English |
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The World Health Organization
2006-07-01
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| Series: | Bulletin of the World Health Organization |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862006000700017&lng=en&tlng=en |
| _version_ | 1827337175146954752 |
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| author | C Kolappan R Subramani K Karunakaran PR Narayanan |
| author_facet | C Kolappan R Subramani K Karunakaran PR Narayanan |
| author_sort | C Kolappan |
| collection | DOAJ |
| description | OBJECTIVE: We aimed to measure the mortality rate and excess general mortality as well as identify groups at high risk for mortality among a cohort of tuberculosis patients treated in Chennai Corporation clinics in south India. METHODS: In this retrospective cohort study we followed up 2674 patients (1800 males and 874 females) who were registered and treated under the DOTS strategy in Chennai Corporation clinics in 2000. The follow-up period from the date of start of treatment to either the date of interview, or death was 600 days. FINDINGS: The mortality rate among this cohort of tuberculosis patients was 60/1000 person-years. The excess general mortality expressed as standardized mortality ratio (SMR) was 6.1 (95% confidence interval (CI) = 5.4-6.9). Younger patients, men, patients with Category II disease, patients who defaulted on, or failed courses of treatment, and male smokers who were alcoholics, all had higher mortality ratios when compared to the rest of the cohort. CONCLUSION: The excess mortality in this cohort was six times more than that in the general population. Young age, male sex, smear-positivity, treatment default, treatment failure and the combination of smoking and alcoholism were identified as risk factors for tuberculosis mortality. We suggest that mortality rate and excess mortality be routinely used as a monitoring tool for evaluating the efficiency of the national control programme. |
| first_indexed | 2024-03-07T18:47:00Z |
| format | Article |
| id | doaj.art-14735e75a95c4f0a8fec2cc8ed34cbfa |
| institution | Directory Open Access Journal |
| issn | 0042-9686 |
| language | English |
| last_indexed | 2024-03-07T18:47:00Z |
| publishDate | 2006-07-01 |
| publisher | The World Health Organization |
| record_format | Article |
| series | Bulletin of the World Health Organization |
| spelling | doaj.art-14735e75a95c4f0a8fec2cc8ed34cbfa2024-03-02T02:18:29ZengThe World Health OrganizationBulletin of the World Health Organization0042-96862006-07-0184755556010.1590/S0042-96862006000700017S0042-96862006000700017Mortality of tuberculosis patients in Chennai, IndiaC Kolappan0R Subramani1K Karunakaran2PR Narayanan3Indian Council of Medical ResearchIndian Council of Medical ResearchChennai CorporationIndian Council of Medical ResearchOBJECTIVE: We aimed to measure the mortality rate and excess general mortality as well as identify groups at high risk for mortality among a cohort of tuberculosis patients treated in Chennai Corporation clinics in south India. METHODS: In this retrospective cohort study we followed up 2674 patients (1800 males and 874 females) who were registered and treated under the DOTS strategy in Chennai Corporation clinics in 2000. The follow-up period from the date of start of treatment to either the date of interview, or death was 600 days. FINDINGS: The mortality rate among this cohort of tuberculosis patients was 60/1000 person-years. The excess general mortality expressed as standardized mortality ratio (SMR) was 6.1 (95% confidence interval (CI) = 5.4-6.9). Younger patients, men, patients with Category II disease, patients who defaulted on, or failed courses of treatment, and male smokers who were alcoholics, all had higher mortality ratios when compared to the rest of the cohort. CONCLUSION: The excess mortality in this cohort was six times more than that in the general population. Young age, male sex, smear-positivity, treatment default, treatment failure and the combination of smoking and alcoholism were identified as risk factors for tuberculosis mortality. We suggest that mortality rate and excess mortality be routinely used as a monitoring tool for evaluating the efficiency of the national control programme.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862006000700017&lng=en&tlng=en |
| spellingShingle | C Kolappan R Subramani K Karunakaran PR Narayanan Mortality of tuberculosis patients in Chennai, India Bulletin of the World Health Organization |
| title | Mortality of tuberculosis patients in Chennai, India |
| title_full | Mortality of tuberculosis patients in Chennai, India |
| title_fullStr | Mortality of tuberculosis patients in Chennai, India |
| title_full_unstemmed | Mortality of tuberculosis patients in Chennai, India |
| title_short | Mortality of tuberculosis patients in Chennai, India |
| title_sort | mortality of tuberculosis patients in chennai india |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862006000700017&lng=en&tlng=en |
| work_keys_str_mv | AT ckolappan mortalityoftuberculosispatientsinchennaiindia AT rsubramani mortalityoftuberculosispatientsinchennaiindia AT kkarunakaran mortalityoftuberculosispatientsinchennaiindia AT prnarayanan mortalityoftuberculosispatientsinchennaiindia |