Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion
Objective To determine the clinicopathological features and prognostic differences between ductal carcinoma in situ (DCIS) and ductal carcinoma in situ with microinvasion (DCIS-MI) of breast cancer. Methods A cohort of 489 female patients with surgically diagnosed DCIS (n=240, 49.1%) and DCIS-MI (n=...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2020-07-01
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| Series: | Di-san junyi daxue xuebao |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202002067.htm |
| _version_ | 1818381194855710720 |
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| author | LIU Jing ZHANG Ye YAN Wenting ZHONG Ling TAN Xuanni |
| author_facet | LIU Jing ZHANG Ye YAN Wenting ZHONG Ling TAN Xuanni |
| author_sort | LIU Jing |
| collection | DOAJ |
| description | Objective To determine the clinicopathological features and prognostic differences between ductal carcinoma in situ (DCIS) and ductal carcinoma in situ with microinvasion (DCIS-MI) of breast cancer. Methods A cohort of 489 female patients with surgically diagnosed DCIS (n=240, 49.1%) and DCIS-MI (n=249, 50.9%) in our hospital from January 2004 to December 2014 were recruited in this study. Their clinicopathological data and follow-up data were collected and analyzed for the differences in clinicopathological data, molecular subtypes and prognosis between DCIS and DCIS-MI patients. Results The age of initial diagnosis was usually younger than 55 years old (60.3%) in the 2 groups. Compared with DCIS patients, DCIS-MI patients had larger tumor size (P=0.034), higher histological grade (P < 0.05), and lower ER positive rate (P < 0.05); DCIS-MI patients had lower proportion of luminal-A type (54.6% vs 63.8%, P=0.040), while higher HER-2 over-expressed type (18.1% vs 9.2%, P=0.004). Statistical differences were seen in the distribution of molecular subtypes between the groups (Chi-square=8.921, P=0.030). The 5-year disease-free survival rate was 93.75% and 93.17% respectively in the DCIS and DCIS-MI patients, with no significant difference (Log-rank, Chi-square =0.074, P=0.785). Conclusion DCIS and DCIS-MI have different clinicopathological features and molecular subtype distribution, but no significant difference in prognosis, which indicates that they may be in different stages of breast cancer progression. |
| first_indexed | 2024-12-14T02:30:42Z |
| format | Article |
| id | doaj.art-14737ab80fe34e96afa0d72ac85bbc4e |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-14T02:30:42Z |
| publishDate | 2020-07-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-14737ab80fe34e96afa0d72ac85bbc4e2022-12-21T23:20:15ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042020-07-0142131355135910.16016/j.1000-5404.202002067Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasionLIU Jing0ZHANG Ye1YAN Wenting2ZHONG Ling3TAN Xuanni4Department of Breast and Thyroid Surgery, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Department of Breast and Thyroid Surgery, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Department of Breast and Thyroid Surgery, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Department of Breast and Thyroid Surgery, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Department of Breast and Thyroid Surgery, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Objective To determine the clinicopathological features and prognostic differences between ductal carcinoma in situ (DCIS) and ductal carcinoma in situ with microinvasion (DCIS-MI) of breast cancer. Methods A cohort of 489 female patients with surgically diagnosed DCIS (n=240, 49.1%) and DCIS-MI (n=249, 50.9%) in our hospital from January 2004 to December 2014 were recruited in this study. Their clinicopathological data and follow-up data were collected and analyzed for the differences in clinicopathological data, molecular subtypes and prognosis between DCIS and DCIS-MI patients. Results The age of initial diagnosis was usually younger than 55 years old (60.3%) in the 2 groups. Compared with DCIS patients, DCIS-MI patients had larger tumor size (P=0.034), higher histological grade (P < 0.05), and lower ER positive rate (P < 0.05); DCIS-MI patients had lower proportion of luminal-A type (54.6% vs 63.8%, P=0.040), while higher HER-2 over-expressed type (18.1% vs 9.2%, P=0.004). Statistical differences were seen in the distribution of molecular subtypes between the groups (Chi-square=8.921, P=0.030). The 5-year disease-free survival rate was 93.75% and 93.17% respectively in the DCIS and DCIS-MI patients, with no significant difference (Log-rank, Chi-square =0.074, P=0.785). Conclusion DCIS and DCIS-MI have different clinicopathological features and molecular subtype distribution, but no significant difference in prognosis, which indicates that they may be in different stages of breast cancer progression.http://aammt.tmmu.edu.cn/Upload/rhtml/202002067.htmbreast cancerductal carcinoma in situductal carcinoma in situ with microinvasionmolecular subtypes |
| spellingShingle | LIU Jing ZHANG Ye YAN Wenting ZHONG Ling TAN Xuanni Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion Di-san junyi daxue xuebao breast cancer ductal carcinoma in situ ductal carcinoma in situ with microinvasion molecular subtypes |
| title | Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion |
| title_full | Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion |
| title_fullStr | Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion |
| title_full_unstemmed | Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion |
| title_short | Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion |
| title_sort | clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion |
| topic | breast cancer ductal carcinoma in situ ductal carcinoma in situ with microinvasion molecular subtypes |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202002067.htm |
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