Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy
A tertiary lymphoid structure (TLS) is a special component in the immune microenvironment that is mainly composed of tumor-infiltrating lymphocytes (TILs), including T cells, B cells, DC cells, and high endothelial venules (HEVs). For cancer patients, evaluation of the immune microenvironment has a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/23/5968 |
| _version_ | 1797463462331285504 |
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| author | Ji’an Zou Yingzhe Zhang Yue Zeng Yurong Peng Junqi Liu Chaoyue Xiao Fang Wu |
| author_facet | Ji’an Zou Yingzhe Zhang Yue Zeng Yurong Peng Junqi Liu Chaoyue Xiao Fang Wu |
| author_sort | Ji’an Zou |
| collection | DOAJ |
| description | A tertiary lymphoid structure (TLS) is a special component in the immune microenvironment that is mainly composed of tumor-infiltrating lymphocytes (TILs), including T cells, B cells, DC cells, and high endothelial venules (HEVs). For cancer patients, evaluation of the immune microenvironment has a predictive effect on tumor biological behavior, treatment methods, and prognosis. As a result, TLSs have begun to attract the attention of researchers as a new potential biomarker. However, the composition and mechanisms of TLSs are still unclear, and clinical detection methods are still being explored. Although some meaningful results have been obtained in clinical trials, there is still a long way to go before such methods can be applied in clinical practice. However, we believe that with the continuous progress of basic research and clinical trials, TLS detection and related treatment can benefit more and more patients. In this review, we generalize the definition and composition of TLSs, summarize clinical trials involving TLSs according to treatment methods, and describe possible methods of inducing TLS formation. |
| first_indexed | 2024-03-09T17:51:03Z |
| format | Article |
| id | doaj.art-14737bce9aaa42868fbe0fc5824cc963 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:51:03Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-14737bce9aaa42868fbe0fc5824cc9632023-11-24T10:41:38ZengMDPI AGCancers2072-66942022-12-011423596810.3390/cancers14235968Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer TherapyJi’an Zou0Yingzhe Zhang1Yue Zeng2Yurong Peng3Junqi Liu4Chaoyue Xiao5Fang Wu6Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410011, ChinaA tertiary lymphoid structure (TLS) is a special component in the immune microenvironment that is mainly composed of tumor-infiltrating lymphocytes (TILs), including T cells, B cells, DC cells, and high endothelial venules (HEVs). For cancer patients, evaluation of the immune microenvironment has a predictive effect on tumor biological behavior, treatment methods, and prognosis. As a result, TLSs have begun to attract the attention of researchers as a new potential biomarker. However, the composition and mechanisms of TLSs are still unclear, and clinical detection methods are still being explored. Although some meaningful results have been obtained in clinical trials, there is still a long way to go before such methods can be applied in clinical practice. However, we believe that with the continuous progress of basic research and clinical trials, TLS detection and related treatment can benefit more and more patients. In this review, we generalize the definition and composition of TLSs, summarize clinical trials involving TLSs according to treatment methods, and describe possible methods of inducing TLS formation.https://www.mdpi.com/2072-6694/14/23/5968tertiary lymphoid structuresimmunotherapychemotherapybiomarkercancer |
| spellingShingle | Ji’an Zou Yingzhe Zhang Yue Zeng Yurong Peng Junqi Liu Chaoyue Xiao Fang Wu Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy Cancers tertiary lymphoid structures immunotherapy chemotherapy biomarker cancer |
| title | Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy |
| title_full | Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy |
| title_fullStr | Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy |
| title_full_unstemmed | Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy |
| title_short | Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy |
| title_sort | tertiary lymphoid structures a potential biomarker for anti cancer therapy |
| topic | tertiary lymphoid structures immunotherapy chemotherapy biomarker cancer |
| url | https://www.mdpi.com/2072-6694/14/23/5968 |
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