Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer
Oral cancer is one of the leading causes of morbidity and mortality globally. There is a lack of studies on the growth of different Candida species in swab pre and post-radiotherapy. Hence, this study aimed to determine different Candida species in the oral cavity of patients who undergo radiothera...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2021-09-01
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| Series: | Journal of Pure and Applied Microbiology |
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| Online Access: | https://microbiologyjournal.org/prevalence-of-different-fungal-species-in-saliva-and-swab-samples-of-patients-undergoing-radiotherapy-for-oral-cancer/ |
| _version_ | 1818647511296901120 |
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| author | Pratima Putta Kannan Natarajan Swapna Sridevi Beeraka Rakesh Kumar Manne Prathi Venkata Sarath |
| author_facet | Pratima Putta Kannan Natarajan Swapna Sridevi Beeraka Rakesh Kumar Manne Prathi Venkata Sarath |
| author_sort | Pratima Putta |
| collection | DOAJ |
| description | Oral cancer is one of the leading causes of morbidity and mortality globally. There is a lack of studies on the growth of different Candida species in swab pre and post-radiotherapy. Hence, this study aimed to determine different Candida species in the oral cavity of patients who undergo radiotherapy. The study included 50 patients with oral cancer scheduled to undergo radiotherapy. Both saliva and swab samples were collected from all the patients before and after two- and six weeks of starting the radiotherapy. Similar inoculation was performed using the salivary swabs and incubated aerobically at 37°C for 48h. After 48h, culture plates were removed from the incubator and observed for the growth of different fungal species based on the color of the colonies. The culture of samples from patients with oral cancer resulted in the growth of 68% of Candida species in saliva and 44% in swab before initiating radiation. Unlike baseline findings, Candida albicans were identified in a higher number in swab samples (44%) than saliva (24%) post two weeks of radiotherapy. All saliva samples were positive to candida species, in which Candida albicans shows high prevalence (24%). After six weeks of radiotherapy, in the swab, 30% of samples were positive for Candida albicans, and 18% of samples were positive for non-albicans species. Before radiotherapy, at two weeks and six weeks of radiotherapy, saliva samples showed a higher prevalence of Candidal species compared to swab samples. The combination of other Candida species was also higher in saliva samples compared to swab samples during radiotherapy. |
| first_indexed | 2024-12-17T01:03:42Z |
| format | Article |
| id | doaj.art-147668d7177a414e9a6cdfc781821114 |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-12-17T01:03:42Z |
| publishDate | 2021-09-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-147668d7177a414e9a6cdfc7818211142022-12-21T22:09:21ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2021-09-011531180118610.22207/JPAM.15.3.07Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral CancerPratima Puttahttps://orcid.org/0000-0001-6309-1075Kannan Natarajanhttps://orcid.org/0000-0002-3278-7018Swapna Sridevi Beerakahttps://orcid.org/0000-0002-6531-2393Rakesh Kumar Mannehttps://orcid.org/0000-0001-5890-8757 Prathi Venkata SarathOral cancer is one of the leading causes of morbidity and mortality globally. There is a lack of studies on the growth of different Candida species in swab pre and post-radiotherapy. Hence, this study aimed to determine different Candida species in the oral cavity of patients who undergo radiotherapy. The study included 50 patients with oral cancer scheduled to undergo radiotherapy. Both saliva and swab samples were collected from all the patients before and after two- and six weeks of starting the radiotherapy. Similar inoculation was performed using the salivary swabs and incubated aerobically at 37°C for 48h. After 48h, culture plates were removed from the incubator and observed for the growth of different fungal species based on the color of the colonies. The culture of samples from patients with oral cancer resulted in the growth of 68% of Candida species in saliva and 44% in swab before initiating radiation. Unlike baseline findings, Candida albicans were identified in a higher number in swab samples (44%) than saliva (24%) post two weeks of radiotherapy. All saliva samples were positive to candida species, in which Candida albicans shows high prevalence (24%). After six weeks of radiotherapy, in the swab, 30% of samples were positive for Candida albicans, and 18% of samples were positive for non-albicans species. Before radiotherapy, at two weeks and six weeks of radiotherapy, saliva samples showed a higher prevalence of Candidal species compared to swab samples. The combination of other Candida species was also higher in saliva samples compared to swab samples during radiotherapy.https://microbiologyjournal.org/prevalence-of-different-fungal-species-in-saliva-and-swab-samples-of-patients-undergoing-radiotherapy-for-oral-cancer/candida albicansoral cancersalivaswabradiotherapy |
| spellingShingle | Pratima Putta Kannan Natarajan Swapna Sridevi Beeraka Rakesh Kumar Manne Prathi Venkata Sarath Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer Journal of Pure and Applied Microbiology candida albicans oral cancer saliva swab radiotherapy |
| title | Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer |
| title_full | Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer |
| title_fullStr | Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer |
| title_full_unstemmed | Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer |
| title_short | Prevalence of different fungal species in Saliva and Swab samples of patients undergoing Radiotherapy for Oral Cancer |
| title_sort | prevalence of different fungal species in saliva and swab samples of patients undergoing radiotherapy for oral cancer |
| topic | candida albicans oral cancer saliva swab radiotherapy |
| url | https://microbiologyjournal.org/prevalence-of-different-fungal-species-in-saliva-and-swab-samples-of-patients-undergoing-radiotherapy-for-oral-cancer/ |
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