Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways
The Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease. A crucial requirement for maintaining Golgi homeostasis is the ability of the Golgi to target aberrant, misfolded,...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/5/780 |
| _version_ | 1797475383828807680 |
|---|---|
| author | Ron Benyair Avital Eisenberg-Lerner Yifat Merbl |
| author_facet | Ron Benyair Avital Eisenberg-Lerner Yifat Merbl |
| author_sort | Ron Benyair |
| collection | DOAJ |
| description | The Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease. A crucial requirement for maintaining Golgi homeostasis is the ability of the Golgi to target aberrant, misfolded, or otherwise unwanted proteins to degradation. Recent studies have revealed that the Golgi apparatus may degrade such proteins through autophagy, retrograde trafficking to the ER for ER-associated degradation (ERAD), and locally, through Golgi apparatus-related degradation (GARD). Here, we review recent discoveries in these mechanisms, highlighting the role of the Golgi in maintaining cellular homeostasis. |
| first_indexed | 2024-03-09T20:44:22Z |
| format | Article |
| id | doaj.art-147876d29c6f4af2a8d02c1b463fa7c1 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:44:22Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-147876d29c6f4af2a8d02c1b463fa7c12023-11-23T22:50:10ZengMDPI AGCells2073-44092022-02-0111578010.3390/cells11050780Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic PathwaysRon Benyair0Avital Eisenberg-Lerner1Yifat Merbl2Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, IsraelDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, IsraelDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, IsraelThe Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease. A crucial requirement for maintaining Golgi homeostasis is the ability of the Golgi to target aberrant, misfolded, or otherwise unwanted proteins to degradation. Recent studies have revealed that the Golgi apparatus may degrade such proteins through autophagy, retrograde trafficking to the ER for ER-associated degradation (ERAD), and locally, through Golgi apparatus-related degradation (GARD). Here, we review recent discoveries in these mechanisms, highlighting the role of the Golgi in maintaining cellular homeostasis.https://www.mdpi.com/2073-4409/11/5/780GolgiproteostasisEGADGARDGOMEDautophagy |
| spellingShingle | Ron Benyair Avital Eisenberg-Lerner Yifat Merbl Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways Cells Golgi proteostasis EGAD GARD GOMED autophagy |
| title | Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways |
| title_full | Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways |
| title_fullStr | Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways |
| title_full_unstemmed | Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways |
| title_short | Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways |
| title_sort | maintaining golgi homeostasis a balancing act of two proteolytic pathways |
| topic | Golgi proteostasis EGAD GARD GOMED autophagy |
| url | https://www.mdpi.com/2073-4409/11/5/780 |
| work_keys_str_mv | AT ronbenyair maintaininggolgihomeostasisabalancingactoftwoproteolyticpathways AT avitaleisenberglerner maintaininggolgihomeostasisabalancingactoftwoproteolyticpathways AT yifatmerbl maintaininggolgihomeostasisabalancingactoftwoproteolyticpathways |