Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study
Abstract Background To investigate the epidemiological, clinical characteristics and outcomes of diabetes in pregnancy (DIP). Methods This single-center, retrospective study included 16,974 pregnant women hospitalized during 2018–2019. Among them, 2860 DIP patients were grouped according to diabetes...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-022-04712-0 |
| _version_ | 1811248789043806208 |
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| author | Jia Chen Zhenyu Wang Weizhen Wu Haixia Chen Caijuan Zhong Lixuan Liang Yingtao Li |
| author_facet | Jia Chen Zhenyu Wang Weizhen Wu Haixia Chen Caijuan Zhong Lixuan Liang Yingtao Li |
| author_sort | Jia Chen |
| collection | DOAJ |
| description | Abstract Background To investigate the epidemiological, clinical characteristics and outcomes of diabetes in pregnancy (DIP). Methods This single-center, retrospective study included 16,974 pregnant women hospitalized during 2018–2019. Among them, 2860 DIP patients were grouped according to diabetes type, glycemic status, and insulin use. Multivariate logistic regression analysis was conducted. Results The incidence of DIP [17.10%; pregestational diabetes mellitus (PGDM), 2.00% (type I, 0.08%; type 2, 1.92%); gestational diabetes mellitus (GDM), 14.85% (GDM A1, 13.58%; GDM A2, 1.27%)] increased annually. Premature birth, congenital anomalies, large for gestational age (LGA), neonatal asphyxia, neonatal intensive care unit transfer, hypertension, and puerperal infection were more common in DIP than in healthy pregnancies. The most common comorbidities/complications were hypertension, thyroid dysfunction, cervical incompetence, intrahepatic cholestasis, premature membrane rupture, oligo/polyhydramnios, and fetal distress. GDM incidence at ages ≥35 and ≥ 45 years was 1.91 and 3.26 times that at age < 35 years, respectively. If only women with high-risk factors were screened, 34.8% GDM cases would be missed. The proportion of insulin use was 14.06% (PGDM, 55%; GDM, 8.53%). Mean gestational age at peak insulin dose in DIP was 32.87 ± 5.46 weeks. Peak insulin doses in PGDM and GDM were 3.67 and 2 times the initial doses, respectively. The risks of LGA, premature birth, cesarean section, and neonatal hypoglycemia in PGDM were 1.845, 1.533, 1.797, and 1.368 times of those in GDM, respectively. The risks of premature birth and neonatal hypoglycemia in women with poor glycemic control were 1.504 and 1.558 times of those in women with good control, respectively. Conclusions The incidence of adverse outcomes in DIP is high. |
| first_indexed | 2024-04-12T15:34:10Z |
| format | Article |
| id | doaj.art-1478c1f1241949a0ac69b848a6ef0583 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-12T15:34:10Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-1478c1f1241949a0ac69b848a6ef05832022-12-22T03:26:59ZengBMCBMC Pregnancy and Childbirth1471-23932022-05-0122111710.1186/s12884-022-04712-0Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective studyJia Chen0Zhenyu Wang1Weizhen Wu2Haixia Chen3Caijuan Zhong4Lixuan Liang5Yingtao Li6Department of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Obstetrics, Foshan Women and Children hospitalDepartment of Obstetrics, Guangdong Women and Children HospitalDepartment of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical UniversityAbstract Background To investigate the epidemiological, clinical characteristics and outcomes of diabetes in pregnancy (DIP). Methods This single-center, retrospective study included 16,974 pregnant women hospitalized during 2018–2019. Among them, 2860 DIP patients were grouped according to diabetes type, glycemic status, and insulin use. Multivariate logistic regression analysis was conducted. Results The incidence of DIP [17.10%; pregestational diabetes mellitus (PGDM), 2.00% (type I, 0.08%; type 2, 1.92%); gestational diabetes mellitus (GDM), 14.85% (GDM A1, 13.58%; GDM A2, 1.27%)] increased annually. Premature birth, congenital anomalies, large for gestational age (LGA), neonatal asphyxia, neonatal intensive care unit transfer, hypertension, and puerperal infection were more common in DIP than in healthy pregnancies. The most common comorbidities/complications were hypertension, thyroid dysfunction, cervical incompetence, intrahepatic cholestasis, premature membrane rupture, oligo/polyhydramnios, and fetal distress. GDM incidence at ages ≥35 and ≥ 45 years was 1.91 and 3.26 times that at age < 35 years, respectively. If only women with high-risk factors were screened, 34.8% GDM cases would be missed. The proportion of insulin use was 14.06% (PGDM, 55%; GDM, 8.53%). Mean gestational age at peak insulin dose in DIP was 32.87 ± 5.46 weeks. Peak insulin doses in PGDM and GDM were 3.67 and 2 times the initial doses, respectively. The risks of LGA, premature birth, cesarean section, and neonatal hypoglycemia in PGDM were 1.845, 1.533, 1.797, and 1.368 times of those in GDM, respectively. The risks of premature birth and neonatal hypoglycemia in women with poor glycemic control were 1.504 and 1.558 times of those in women with good control, respectively. Conclusions The incidence of adverse outcomes in DIP is high.https://doi.org/10.1186/s12884-022-04712-0PregnancyDiabetesClinical characteristicInsulinPregnancy outcome |
| spellingShingle | Jia Chen Zhenyu Wang Weizhen Wu Haixia Chen Caijuan Zhong Lixuan Liang Yingtao Li Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study BMC Pregnancy and Childbirth Pregnancy Diabetes Clinical characteristic Insulin Pregnancy outcome |
| title | Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study |
| title_full | Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study |
| title_fullStr | Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study |
| title_full_unstemmed | Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study |
| title_short | Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study |
| title_sort | clinical analysis of 2860 cases of diabetes in pregnancy a single center retrospective study |
| topic | Pregnancy Diabetes Clinical characteristic Insulin Pregnancy outcome |
| url | https://doi.org/10.1186/s12884-022-04712-0 |
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