Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients.

Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients.

BACKGROUND: Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe fact...

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Bibliographic Details
Main Authors: Jakob G Jespersen, Anders Nedergaard, Søren Reitelseder, Ulla R Mikkelsen, Kasper J Dideriksen, Jakob Agergaard, Frederik Kreiner, Frank C Pott, Peter Schjerling, Michael Kjaer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3069050?pdf=render

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