Improvement in Survival Outcomes of Acute Lymphoblastic Leukemia Patients Treated With Berlin-Frankfurt-Munster 76/79 Protocol
Introduction: Acute lymphoblastic leukemia (ALL) is a malignancy of the white blood cells and lymphoid lines of hematopoietic cells in the blood and bone marrow while lymphomas mostly involve the lymph nodes. This study showed the response rate of ALL treated with BFM (Berlin-Frankfurt-Munster) 76/7...
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| Format: | Article |
| Language: | English |
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Shaikh Zayed Medical Complex, Lahore
2021-01-01
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| Series: | Proceedings |
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| Online Access: | https://proceedings-szmc.org.pk/index.php/szmc/article/view/70 |
| _version_ | 1817985891464904704 |
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| author | Khansa Saleem Muhammad Ilyas Saad Razzaq Fahad Maqbool Qaiser Abbas Aneem Abdullah Abu Bakar Shahid |
| author_facet | Khansa Saleem Muhammad Ilyas Saad Razzaq Fahad Maqbool Qaiser Abbas Aneem Abdullah Abu Bakar Shahid |
| author_sort | Khansa Saleem |
| collection | DOAJ |
| description | Introduction: Acute lymphoblastic leukemia (ALL) is a malignancy of the white blood cells and lymphoid lines of hematopoietic cells in the blood and bone marrow while lymphomas mostly involve the lymph nodes. This study showed the response rate of ALL treated with BFM (Berlin-Frankfurt-Munster) 76/79 protocol.
Aims & Objectives: To study the effects of WBC (White Blood Cells), age, and treatment protocols on the survival of ALL patients to BFM 76/79 protocol and other chemotherapy protocol.
Place and duration of study: 6 months retrospective study on 2015-2017 indoor patient data from INMOL Hospital Lahore, Pakistan.
Material & Methods: Data of 129 patients was assessed for eligibility, and 84 patients of ALL selected. Clinical information of patients regarding Gender, Age, WBC, Fever, Hepatosplenomegaly, Lymphadenopathy, Bleeding, Bone Pain, Immunophenotype, Relapse, Death, and survival rates were recorded. Patients were grouped according to Age, WBC, Gender, and Immunophenotype. Patients were treated with BFM 76/79 Protocols and the remaining patients were treated with other protocols (CALGB, FLAG-TDA, Hyper-CVAD, EURO, COG, T-Cell ALL protocol, and ALL protocol 9111).
Results: Out of 84 patients, 55 (65.5%) patients were treated with Berlin-Frankfurt-Munster 76/79 protocol and the remaining 20 (23.81%) patients with other protocols. After the end of induction 64 (73.8%) patients achieved complete remission and 5 (5.95%) patients did not achieve Remission.
Conclusion: Response rate of ALL (Acute Lymphoblastic Leukemia) patients treated with BFM 76/79 protocol was better than other protocols and possibly when risk adapted for male gender, WBC > 50 x 109/L and age> 30 years. |
| first_indexed | 2024-04-14T00:03:40Z |
| format | Article |
| id | doaj.art-147a8919e7b54f5497478f89ce90324f |
| institution | Directory Open Access Journal |
| issn | 1815-4905 2518-203X |
| language | English |
| last_indexed | 2024-04-14T00:03:40Z |
| publishDate | 2021-01-01 |
| publisher | Shaikh Zayed Medical Complex, Lahore |
| record_format | Article |
| series | Proceedings |
| spelling | doaj.art-147a8919e7b54f5497478f89ce90324f2022-12-22T02:23:37ZengShaikh Zayed Medical Complex, LahoreProceedings1815-49052518-203X2021-01-0135171110.47489/p000s351z7761-5mc70Improvement in Survival Outcomes of Acute Lymphoblastic Leukemia Patients Treated With Berlin-Frankfurt-Munster 76/79 ProtocolKhansa Saleem0Muhammad Ilyas1Saad Razzaq2Fahad Maqbool3Qaiser Abbas4Aneem Abdullah5Abu Bakar Shahid6Department of Computer Sciences& Information Technology, University of Sargodha, Sargodha Department of Computer Sciences& Information Technology, University of Sargodha, Sargodha Department of Computer Sciences& Information Technology, University of Sargodha, Sargodha Department of Computer Sciences& Information Technology, University of Sargodha, Sargodha Department of Computer Sciences& Information Technology, University of Sargodha, Sargodha Department of Nephrology, Shaikh Zayed Medical Complex, Lahore INMOL Cancer Hospital, Lahore Introduction: Acute lymphoblastic leukemia (ALL) is a malignancy of the white blood cells and lymphoid lines of hematopoietic cells in the blood and bone marrow while lymphomas mostly involve the lymph nodes. This study showed the response rate of ALL treated with BFM (Berlin-Frankfurt-Munster) 76/79 protocol. Aims & Objectives: To study the effects of WBC (White Blood Cells), age, and treatment protocols on the survival of ALL patients to BFM 76/79 protocol and other chemotherapy protocol. Place and duration of study: 6 months retrospective study on 2015-2017 indoor patient data from INMOL Hospital Lahore, Pakistan. Material & Methods: Data of 129 patients was assessed for eligibility, and 84 patients of ALL selected. Clinical information of patients regarding Gender, Age, WBC, Fever, Hepatosplenomegaly, Lymphadenopathy, Bleeding, Bone Pain, Immunophenotype, Relapse, Death, and survival rates were recorded. Patients were grouped according to Age, WBC, Gender, and Immunophenotype. Patients were treated with BFM 76/79 Protocols and the remaining patients were treated with other protocols (CALGB, FLAG-TDA, Hyper-CVAD, EURO, COG, T-Cell ALL protocol, and ALL protocol 9111). Results: Out of 84 patients, 55 (65.5%) patients were treated with Berlin-Frankfurt-Munster 76/79 protocol and the remaining 20 (23.81%) patients with other protocols. After the end of induction 64 (73.8%) patients achieved complete remission and 5 (5.95%) patients did not achieve Remission. Conclusion: Response rate of ALL (Acute Lymphoblastic Leukemia) patients treated with BFM 76/79 protocol was better than other protocols and possibly when risk adapted for male gender, WBC > 50 x 109/L and age> 30 years.https://proceedings-szmc.org.pk/index.php/szmc/article/view/70acute lymphoblastic leukemia (all), bfm protocols, acute myeloid leukemia (aml), non- hodgkin lymphoma (nhl) |
| spellingShingle | Khansa Saleem Muhammad Ilyas Saad Razzaq Fahad Maqbool Qaiser Abbas Aneem Abdullah Abu Bakar Shahid Improvement in Survival Outcomes of Acute Lymphoblastic Leukemia Patients Treated With Berlin-Frankfurt-Munster 76/79 Protocol Proceedings acute lymphoblastic leukemia (all), bfm protocols, acute myeloid leukemia (aml), non- hodgkin lymphoma (nhl) |
| title | Improvement in Survival Outcomes of Acute Lymphoblastic Leukemia Patients Treated With Berlin-Frankfurt-Munster 76/79 Protocol |
| title_full | Improvement in Survival Outcomes of Acute Lymphoblastic Leukemia Patients Treated With Berlin-Frankfurt-Munster 76/79 Protocol |
| title_fullStr | Improvement in Survival Outcomes of Acute Lymphoblastic Leukemia Patients Treated With Berlin-Frankfurt-Munster 76/79 Protocol |
| title_full_unstemmed | Improvement in Survival Outcomes of Acute Lymphoblastic Leukemia Patients Treated With Berlin-Frankfurt-Munster 76/79 Protocol |
| title_short | Improvement in Survival Outcomes of Acute Lymphoblastic Leukemia Patients Treated With Berlin-Frankfurt-Munster 76/79 Protocol |
| title_sort | improvement in survival outcomes of acute lymphoblastic leukemia patients treated with berlin frankfurt munster 76 79 protocol |
| topic | acute lymphoblastic leukemia (all), bfm protocols, acute myeloid leukemia (aml), non- hodgkin lymphoma (nhl) |
| url | https://proceedings-szmc.org.pk/index.php/szmc/article/view/70 |
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