Premature Ovarian Failure: An Association with Autoimmune Diseases
Introduction: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases. Aim: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. Mater...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/8671/22027_CE(RA1)_F(T)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818188131695853568 |
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| author | Ayesha Vandana Jha Deepti Goswami |
| author_facet | Ayesha Vandana Jha Deepti Goswami |
| author_sort | Ayesha |
| collection | DOAJ |
| description | Introduction: Premature Ovarian Failure (POF) is the cessation
of ovarian function before the age of 40 years. POF is reported to
be associated with autoimmune diseases in 20-30% of cases.
Aim: Patients presenting with idiopathic POF were screened for
the presence of autoimmune disorders.
Materials and Methods: Twenty patients with idiopathic POF
were included in the study. Baseline investigation in all subjects
included fasting serum FSH, LH, E2, progesterone, free T3, free
T4, Thyroid-Stimulating Hormone (TSH) and Anti-Thyroperoxidase
(anti-TPO) antibodies, testosterone and Dehydroepiandrosterone
(DHEAS) levels. Fasting and post-glucose (2 hours after 75g
of oral glucose) serum calcium and phosphate were estimated
using appropriate assays in biochemistry laboratory.
Results: Seven patients (35%), who presented with secondary
amenorrhea, had thyroid disorders and were already on thyroxine
replacement therapy. One patient also had vitiligo. There was
no history of adrenal disorder. Anti-TPO levels were elevated in
two (10%) patients of secondary amenorrhea group. The levels
of serum testosterone were low in three patients. Serum DHEAS
levels were low in 13 patients. Blood sugar levels (fasting and
2 hour post 75g glucose load) and fasting insulin levels were
normal. Serum calcium and phosphate levels were normal in all
the patients.
Conclusion: Thyroid autoimmunity is the most common
autoimmune disease associated with POF. The finding of low
DHEAS in a large percentage of patients (65%), suggests
possibility of adrenal dysfunction. This requires further testing
for adrenal reserve and adrenal autoantibodies. |
| first_indexed | 2024-12-11T23:22:03Z |
| format | Article |
| id | doaj.art-147bd188adff49c399ffd7720ba18096 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T23:22:03Z |
| publishDate | 2016-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-147bd188adff49c399ffd7720ba180962022-12-22T00:46:18ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-10-011010QC10QC1210.7860/JCDR/2016/22027.8671Premature Ovarian Failure: An Association with Autoimmune DiseasesAyesha0Vandana Jha1Deepti Goswami2Assistant Professor, Department of Obstetrics and Gynecology, Mayo Institute of Medical Sciences, Barabanki, U.P., India.Assistant Professor, Department of Obstetrics and Gynecology, Mayo Institute of Medical Sciences, Barabanki, U.P., India.Professor, Department of Obstetrics and Gynecology, Maulana Azad Medical College, New Delhi, India.Introduction: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases. Aim: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. Materials and Methods: Twenty patients with idiopathic POF were included in the study. Baseline investigation in all subjects included fasting serum FSH, LH, E2, progesterone, free T3, free T4, Thyroid-Stimulating Hormone (TSH) and Anti-Thyroperoxidase (anti-TPO) antibodies, testosterone and Dehydroepiandrosterone (DHEAS) levels. Fasting and post-glucose (2 hours after 75g of oral glucose) serum calcium and phosphate were estimated using appropriate assays in biochemistry laboratory. Results: Seven patients (35%), who presented with secondary amenorrhea, had thyroid disorders and were already on thyroxine replacement therapy. One patient also had vitiligo. There was no history of adrenal disorder. Anti-TPO levels were elevated in two (10%) patients of secondary amenorrhea group. The levels of serum testosterone were low in three patients. Serum DHEAS levels were low in 13 patients. Blood sugar levels (fasting and 2 hour post 75g glucose load) and fasting insulin levels were normal. Serum calcium and phosphate levels were normal in all the patients. Conclusion: Thyroid autoimmunity is the most common autoimmune disease associated with POF. The finding of low DHEAS in a large percentage of patients (65%), suggests possibility of adrenal dysfunction. This requires further testing for adrenal reserve and adrenal autoantibodies.https://jcdr.net/articles/PDF/8671/22027_CE(RA1)_F(T)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdfamenorrheaautoimmunitythyroid autoantibodies |
| spellingShingle | Ayesha Vandana Jha Deepti Goswami Premature Ovarian Failure: An Association with Autoimmune Diseases Journal of Clinical and Diagnostic Research amenorrhea autoimmunity thyroid autoantibodies |
| title | Premature Ovarian Failure: An Association with Autoimmune Diseases |
| title_full | Premature Ovarian Failure: An Association with Autoimmune Diseases |
| title_fullStr | Premature Ovarian Failure: An Association with Autoimmune Diseases |
| title_full_unstemmed | Premature Ovarian Failure: An Association with Autoimmune Diseases |
| title_short | Premature Ovarian Failure: An Association with Autoimmune Diseases |
| title_sort | premature ovarian failure an association with autoimmune diseases |
| topic | amenorrhea autoimmunity thyroid autoantibodies |
| url | https://jcdr.net/articles/PDF/8671/22027_CE(RA1)_F(T)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
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