MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1

MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1

Abstract Background Patients with diabetes have an increased risk of nonunion and delayed union of fractures. Macrophages have been shown as a key player in diabetic complications. However, it remains obscure how diabetic milieu affects macrophage-derived exosomes and its implications on osteogenic...

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Bibliographic Details
Main Authors: Dong Zhang, Yifan Wu, Zonghuan Li, Hairen Chen, Siyuan Huang, Chao Jian, Aixi Yu
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Nanobiotechnology
Subjects:
Exosome
Macrophage
MiR-144-5p
Osteoblast
Fracture
Smad1
Online Access:https://doi.org/10.1186/s12951-021-00964-8

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