Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at Risk for Treatment-Related Adverse Events in Head and Neck Cancer
A low skeletal muscle index (SMI), defined with cut-off values, is a promising predictor for adverse events (AEs) in head and neck squamous cell cancer (HNSCC) patients. The aim was to generate sex-specific SMI cut-off values based on AE to diagnose low SMI and to analyse the relationship between lo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/16/4650 |
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| author | Aniek T. Zwart Wolf Pörtzgen Irene van Rijn-Dekker Grigory A. Sidorenkov Rudi A. J. O. Dierckx Roel J. H. M. Steenbakkers Inge Wegner Anouk van der Hoorn Geertruida H. de Bock Gyorgy B. Halmos |
| author_facet | Aniek T. Zwart Wolf Pörtzgen Irene van Rijn-Dekker Grigory A. Sidorenkov Rudi A. J. O. Dierckx Roel J. H. M. Steenbakkers Inge Wegner Anouk van der Hoorn Geertruida H. de Bock Gyorgy B. Halmos |
| author_sort | Aniek T. Zwart |
| collection | DOAJ |
| description | A low skeletal muscle index (SMI), defined with cut-off values, is a promising predictor for adverse events (AEs) in head and neck squamous cell cancer (HNSCC) patients. The aim was to generate sex-specific SMI cut-off values based on AE to diagnose low SMI and to analyse the relationship between low SMI and AEs in HNSCC patients. In this present study, HNSCC patients were prospectively included in a large oncological data-biobank and SMI was retrospectively measured using baseline neck scans. In total, 193 patients were included and were stratified according to treatment modality: (chemo-)radiotherapy ((C)RT) (n = 135) and surgery (n = 61). AE endpoints were based on the occurrence of clinically relevant toxicities (Common Terminology Criteria for Adverse Events grade ≥ III) and postoperative complications (Clavien–Dindo Classification grade ≥ II). Sex-specific SMI cut-off values were generated with receiver operating characteristic curves, based on the AE endpoints. The relationship of the baseline characteristics and AEs was analysed with logistic regression analysis, with AEs as the endpoint. Multivariable logistic analysis showed that low SMI (OR 3.33, 95%CI 1.41–7.85) and tumour stage (OR 3.45, 95%CI 1.28–9.29) were significantly and independently associated to (C)RT toxicity. Low SMI was not related to postoperative complications. To conclude, sex-specific SMI cut-off values, were generated based on the occurrence of AEs. Low SMI and tumour stage were independently related to (C)RT toxicity in HNSCC patients. |
| first_indexed | 2024-03-09T04:16:42Z |
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| id | doaj.art-147e0dd1f70a4085b511b707163469c1 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:16:42Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-147e0dd1f70a4085b511b707163469c12023-12-03T13:51:51ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011116465010.3390/jcm11164650Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at Risk for Treatment-Related Adverse Events in Head and Neck CancerAniek T. Zwart0Wolf Pörtzgen1Irene van Rijn-Dekker2Grigory A. Sidorenkov3Rudi A. J. O. Dierckx4Roel J. H. M. Steenbakkers5Inge Wegner6Anouk van der Hoorn7Geertruida H. de Bock8Gyorgy B. Halmos9Department of Epidemiology, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Otolaryngology and Head and Neck Surgery, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Radiotherapy, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Epidemiology, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Radiology, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Radiotherapy, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Otolaryngology and Head and Neck Surgery, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Radiology, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Epidemiology, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsDepartment of Otolaryngology and Head and Neck Surgery, University Medical Centre Groningen, 9700 RB Groningen, The NetherlandsA low skeletal muscle index (SMI), defined with cut-off values, is a promising predictor for adverse events (AEs) in head and neck squamous cell cancer (HNSCC) patients. The aim was to generate sex-specific SMI cut-off values based on AE to diagnose low SMI and to analyse the relationship between low SMI and AEs in HNSCC patients. In this present study, HNSCC patients were prospectively included in a large oncological data-biobank and SMI was retrospectively measured using baseline neck scans. In total, 193 patients were included and were stratified according to treatment modality: (chemo-)radiotherapy ((C)RT) (n = 135) and surgery (n = 61). AE endpoints were based on the occurrence of clinically relevant toxicities (Common Terminology Criteria for Adverse Events grade ≥ III) and postoperative complications (Clavien–Dindo Classification grade ≥ II). Sex-specific SMI cut-off values were generated with receiver operating characteristic curves, based on the AE endpoints. The relationship of the baseline characteristics and AEs was analysed with logistic regression analysis, with AEs as the endpoint. Multivariable logistic analysis showed that low SMI (OR 3.33, 95%CI 1.41–7.85) and tumour stage (OR 3.45, 95%CI 1.28–9.29) were significantly and independently associated to (C)RT toxicity. Low SMI was not related to postoperative complications. To conclude, sex-specific SMI cut-off values, were generated based on the occurrence of AEs. Low SMI and tumour stage were independently related to (C)RT toxicity in HNSCC patients.https://www.mdpi.com/2077-0383/11/16/4650sarcopeniahead and neck neoplasmsadverse eventspostoperative complicationtoxicitycut-off |
| spellingShingle | Aniek T. Zwart Wolf Pörtzgen Irene van Rijn-Dekker Grigory A. Sidorenkov Rudi A. J. O. Dierckx Roel J. H. M. Steenbakkers Inge Wegner Anouk van der Hoorn Geertruida H. de Bock Gyorgy B. Halmos Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at Risk for Treatment-Related Adverse Events in Head and Neck Cancer Journal of Clinical Medicine sarcopenia head and neck neoplasms adverse events postoperative complication toxicity cut-off |
| title | Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at Risk for Treatment-Related Adverse Events in Head and Neck Cancer |
| title_full | Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at Risk for Treatment-Related Adverse Events in Head and Neck Cancer |
| title_fullStr | Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at Risk for Treatment-Related Adverse Events in Head and Neck Cancer |
| title_full_unstemmed | Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at Risk for Treatment-Related Adverse Events in Head and Neck Cancer |
| title_short | Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at Risk for Treatment-Related Adverse Events in Head and Neck Cancer |
| title_sort | sex specific cut off values for low skeletal muscle mass to identify patients at risk for treatment related adverse events in head and neck cancer |
| topic | sarcopenia head and neck neoplasms adverse events postoperative complication toxicity cut-off |
| url | https://www.mdpi.com/2077-0383/11/16/4650 |
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