Tau <i>N</i>-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model
The microtubule-associated protein tau can undergo liquid–liquid phase separation (LLPS) to form membraneless condensates in neurons, yet the underlying molecular mechanisms and functions of tau LLPS and tau droplets remain to be elucidated. The human brain contains mainly 6 tau isoforms with differ...
Main Authors: | Chengchen Wu, Junyi Zhao, Qiuping Wu, Qiulong Tan, Qiong Liu, Shifeng Xiao |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-09-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/18/9728 |
Similar Items
-
Nuclear face of Tau: an inside player in neurodegeneration
by: Neelam Younas, et al.
Published: (2023-12-01) -
Liquid-liquid phase separation of protein tau: An emerging process in Alzheimer's disease pathogenesis
by: Hassan Ainani, et al.
Published: (2023-03-01) -
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice
by: Suyue Zhong, et al.
Published: (2023-05-01) -
Insights into Disease-Associated Tau Impact on Mitochondria
by: Leonora Szabo, et al.
Published: (2020-09-01) -
Hyperphosphorylation-induced tau oligomers
by: Khalid eIqbal, et al.
Published: (2013-08-01)