Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage
Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-11-01
|
| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1812868 |
| _version_ | 1797677127953285120 |
|---|---|
| author | Toshimichi Yamada Xiaoning Sun Nobuyoshi Akimitsu |
| author_facet | Toshimichi Yamada Xiaoning Sun Nobuyoshi Akimitsu |
| author_sort | Toshimichi Yamada |
| collection | DOAJ |
| description | Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay to activate translesion synthesis (46/50). |
| first_indexed | 2024-03-11T22:39:31Z |
| format | Article |
| id | doaj.art-147f08c0b5e94e97902fe0b4d55cbff6 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:31Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-147f08c0b5e94e97902fe0b4d55cbff62023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-11-017610.1080/23723556.2020.18128681812868Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damageToshimichi Yamada0Xiaoning Sun1Nobuyoshi Akimitsu2Department of Molecular and Cellular Biochemistry, Meiji Pharmaceutical UniversityThe University of TokyoThe University of TokyoBiological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay to activate translesion synthesis (46/50).http://dx.doi.org/10.1080/23723556.2020.1812868pumiliorna stabilityrna-seqtranslesion synthesis |
| spellingShingle | Toshimichi Yamada Xiaoning Sun Nobuyoshi Akimitsu Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage Molecular & Cellular Oncology pumilio rna stability rna-seq translesion synthesis |
| title | Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage |
| title_full | Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage |
| title_fullStr | Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage |
| title_full_unstemmed | Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage |
| title_short | Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage |
| title_sort | repression of pum1 mediated mrna decay activates translesion synthesis after dna damage |
| topic | pumilio rna stability rna-seq translesion synthesis |
| url | http://dx.doi.org/10.1080/23723556.2020.1812868 |
| work_keys_str_mv | AT toshimichiyamada repressionofpum1mediatedmrnadecayactivatestranslesionsynthesisafterdnadamage AT xiaoningsun repressionofpum1mediatedmrnadecayactivatestranslesionsynthesisafterdnadamage AT nobuyoshiakimitsu repressionofpum1mediatedmrnadecayactivatestranslesionsynthesisafterdnadamage |