Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage

Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage

Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay t...

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Bibliographic Details
Main Authors: Toshimichi Yamada, Xiaoning Sun, Nobuyoshi Akimitsu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Molecular & Cellular Oncology
Subjects:
pumilio
rna stability
rna-seq
translesion synthesis
Online Access:http://dx.doi.org/10.1080/23723556.2020.1812868

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