Shaping inhibition: activity dependent structural plasticity of GABAergic synapses
Inhibitory transmission through the neurotransmitter Ɣ-aminobutyric acid (GABA) shapes network activity in the mammalian cerebral cortex by filtering synaptic incoming information and dictating the activity of principal cells. The incredibly diverse population of cortical neurons that use GABA as ne...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00327/full |
| _version_ | 1818544536532549632 |
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| author | Carmen E Flores Pablo eMendez |
| author_facet | Carmen E Flores Pablo eMendez |
| author_sort | Carmen E Flores |
| collection | DOAJ |
| description | Inhibitory transmission through the neurotransmitter Ɣ-aminobutyric acid (GABA) shapes network activity in the mammalian cerebral cortex by filtering synaptic incoming information and dictating the activity of principal cells. The incredibly diverse population of cortical neurons that use GABA as neurotransmitter shows an equally diverse range of mechanisms that regulate changes in the strength of GABAergic synaptic transmission and allow them to dynamically follow and command the activity of neuronal ensembles. Similarly to glutamatergic synaptic transmission, activity-dependent functional changes in inhibitory neurotransmission are accompanied by alterations in GABAergic synapse structure that range from morphological reorganization of postsynaptic density to de novo formation and elimination of inhibitory contacts. Here we review several aspects of structural plasticity of inhibitory synapses, including its induction by different forms of neuronal activity, behavioral and sensory experience and the molecular mechanisms and signaling pathways involved. We discuss the functional consequences of GABAergic synapse structural plasticity for information processing and memory formation in view of the heterogenous nature of the structural plasticity phenomena affecting inhibitory synapses impinging on somatic and dendritic compartments of cortical and hippocampal neurons. |
| first_indexed | 2024-12-11T22:49:47Z |
| format | Article |
| id | doaj.art-14801ac5e09f48998fb2afb938c98216 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T22:49:47Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-14801ac5e09f48998fb2afb938c982162022-12-22T00:47:30ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022014-10-01810.3389/fncel.2014.00327116126Shaping inhibition: activity dependent structural plasticity of GABAergic synapsesCarmen E Flores0Pablo eMendez1University of GenevaUniversity of GenevaInhibitory transmission through the neurotransmitter Ɣ-aminobutyric acid (GABA) shapes network activity in the mammalian cerebral cortex by filtering synaptic incoming information and dictating the activity of principal cells. The incredibly diverse population of cortical neurons that use GABA as neurotransmitter shows an equally diverse range of mechanisms that regulate changes in the strength of GABAergic synaptic transmission and allow them to dynamically follow and command the activity of neuronal ensembles. Similarly to glutamatergic synaptic transmission, activity-dependent functional changes in inhibitory neurotransmission are accompanied by alterations in GABAergic synapse structure that range from morphological reorganization of postsynaptic density to de novo formation and elimination of inhibitory contacts. Here we review several aspects of structural plasticity of inhibitory synapses, including its induction by different forms of neuronal activity, behavioral and sensory experience and the molecular mechanisms and signaling pathways involved. We discuss the functional consequences of GABAergic synapse structural plasticity for information processing and memory formation in view of the heterogenous nature of the structural plasticity phenomena affecting inhibitory synapses impinging on somatic and dendritic compartments of cortical and hippocampal neurons.http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00327/fullCerebral CortexHippocampusMemoryinterneuronstructural plasticityactivity-dependent plasticity |
| spellingShingle | Carmen E Flores Pablo eMendez Shaping inhibition: activity dependent structural plasticity of GABAergic synapses Frontiers in Cellular Neuroscience Cerebral Cortex Hippocampus Memory interneuron structural plasticity activity-dependent plasticity |
| title | Shaping inhibition: activity dependent structural plasticity of GABAergic synapses |
| title_full | Shaping inhibition: activity dependent structural plasticity of GABAergic synapses |
| title_fullStr | Shaping inhibition: activity dependent structural plasticity of GABAergic synapses |
| title_full_unstemmed | Shaping inhibition: activity dependent structural plasticity of GABAergic synapses |
| title_short | Shaping inhibition: activity dependent structural plasticity of GABAergic synapses |
| title_sort | shaping inhibition activity dependent structural plasticity of gabaergic synapses |
| topic | Cerebral Cortex Hippocampus Memory interneuron structural plasticity activity-dependent plasticity |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00327/full |
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